Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3847018..3847675 Replicon chromosome
Accession NZ_CP010376
Organism Enterobacter hormaechei subsp. steigerwaltii strain 34977

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LI62_RS18505 Protein ID WP_017382887.1
Coordinates 3847018..3847428 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LI62_RS18510 Protein ID WP_003863437.1
Coordinates 3847409..3847675 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI62_RS18485 3843016..3844749 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
LI62_RS18490 3844755..3845468 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LI62_RS18495 3845497..3846393 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LI62_RS18500 3846495..3847016 + 522 WP_015571793.1 flavodoxin FldB -
LI62_RS18505 3847018..3847428 - 411 WP_017382887.1 protein YgfX Toxin
LI62_RS18510 3847409..3847675 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LI62_RS18515 3847970..3848950 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
LI62_RS18520 3849062..3849721 - 660 WP_003863433.1 hemolysin III family protein -
LI62_RS18525 3849988..3850719 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
LI62_RS18530 3850836..3852269 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T52282 WP_017382887.1 NZ_CP010376:c3847428-3847018 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T52282 NZ_CP010376:c3847428-3847018 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGCCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT52282 WP_003863437.1 NZ_CP010376:c3847675-3847409 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT52282 NZ_CP010376:c3847675-3847409 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References