Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4308796..4309784 Replicon chromosome
Accession NZ_CP010371
Organism Escherichia coli strain 6409

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag RR31_RS21185 Protein ID WP_014640052.1
Coordinates 4309398..4309784 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0A1AFM1
Locus tag RR31_RS21180 Protein ID WP_000458583.1
Coordinates 4308796..4309368 (+) Length 191 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR31_RS21150 4303884..4304492 + 609 WP_000646078.1 transcriptional repressor LexA -
RR31_RS21155 4304565..4305890 + 1326 WP_039268516.1 MATE family efflux transporter DinF -
RR31_RS21160 4306006..4306215 + 210 WP_001030593.1 CsbD family protein -
RR31_RS21165 4306257..4306772 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
RR31_RS21175 4307090..4308075 + 986 Protein_3997 DUF2713 domain-containing protein -
RR31_RS27220 4308438..4308560 + 123 WP_001300034.1 hypothetical protein -
RR31_RS21180 4308796..4309368 + 573 WP_000458583.1 SocA family protein Antitoxin
RR31_RS21185 4309398..4309784 + 387 WP_014640052.1 hypothetical protein Toxin
RR31_RS29225 4309824..4309997 + 174 WP_000390072.1 hypothetical protein -
RR31_RS21190 4310045..4310326 - 282 WP_001093916.1 pyocin activator PrtN family protein -
RR31_RS21195 4310363..4311115 - 753 WP_187440354.1 hypothetical protein -
RR31_RS21200 4311334..4312158 - 825 WP_000081311.1 DUF2303 family protein -
RR31_RS21205 4312224..4312586 - 363 WP_000135680.1 hypothetical protein -
RR31_RS21210 4313273..4313947 - 675 WP_039268519.1 LexA family transcriptional regulator -
RR31_RS21215 4314038..4314238 + 201 WP_000649477.1 helix-turn-helix domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4303406..4356254 52848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(27-137)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T52252 WP_014640052.1 NZ_CP010371:4309398-4309784 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T52252 NZ_CP010371:4309398-4309784 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21956.30 Da        Isoelectric Point: 6.0283

>AT52252 WP_000458583.1 NZ_CP010371:4308796-4309368 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT52252 NZ_CP010371:4308796-4309368 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTGGTGACTACTGGTACAAC
CTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AFM1

References