Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 14229..14757 Replicon plasmid p6411-89.111kb
Accession NZ_CP010369
Organism Acinetobacter nosocomialis strain 6411

Toxin (Protein)


Gene name relE Uniprot ID B0V430
Locus tag RR32_RS18240 Protein ID WP_000221360.1
Coordinates 14229..14522 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0V429
Locus tag RR32_RS18245 Protein ID WP_000246757.1
Coordinates 14512..14757 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR32_RS18205 10303..10659 + 357 WP_000269908.1 type II toxin-antitoxin system RelE/ParE family toxin -
RR32_RS18210 10652..10912 + 261 WP_002120200.1 helix-turn-helix transcriptional regulator -
RR32_RS18225 12058..12267 - 210 WP_000069470.1 hypothetical protein -
RR32_RS18230 12260..12562 - 303 WP_001140619.1 XRE family transcriptional regulator -
RR32_RS18235 12603..12911 - 309 WP_000269910.1 type II toxin-antitoxin system RelE/ParE family toxin -
RR32_RS19760 13926..14042 - 117 Protein_12 transposase -
RR32_RS18240 14229..14522 - 294 WP_000221360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RR32_RS18245 14512..14757 - 246 WP_000246757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RR32_RS18250 15014..15916 - 903 WP_000466974.1 hypothetical protein -
RR32_RS18255 16124..16636 - 513 WP_001089570.1 SMI1/KNR4 family protein -
RR32_RS18260 16768..17286 - 519 WP_000447196.1 sel1 repeat family protein -
RR32_RS19920 17696..17917 - 222 Protein_18 IS3 family transposase -
RR32_RS19770 18052..18228 - 177 Protein_19 antibiotic biosynthesis monooxygenase -
RR32_RS18265 18227..18811 - 585 Protein_20 alcohol dehydrogenase catalytic domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89111 89111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11317.49 Da        Isoelectric Point: 10.4753

>T52229 WP_000221360.1 NZ_CP010369:c14522-14229 [Acinetobacter nosocomialis]
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T52229 NZ_CP010369:c14522-14229 [Acinetobacter nosocomialis]
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9264.63 Da        Isoelectric Point: 4.2821

>AT52229 WP_000246757.1 NZ_CP010369:c14757-14512 [Acinetobacter nosocomialis]
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L

Download         Length: 246 bp

>AT52229 NZ_CP010369:c14757-14512 [Acinetobacter nosocomialis]
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RR87

Antitoxin

Source ID Structure
AlphaFold DB A0A009MZ79

References