52222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2960283..2960836 Replicon chromosome
Accession NZ_CP010359
Organism Pseudomonas plecoglossicida strain NyZ12

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag RK21_RS29065 Protein ID WP_010953434.1
Coordinates 2960283..2960576 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag RK21_RS13460 Protein ID WP_010953433.1
Coordinates 2960564..2960836 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK21_RS13440 2956123..2956668 - 546 WP_023663373.1 hypothetical protein -
RK21_RS13445 2956661..2957440 - 780 WP_023663372.1 hypothetical protein -
RK21_RS13450 2957692..2958105 + 414 Protein_2701 WYL domain-containing protein -
RK21_RS13455 2958880..2960289 + 1410 WP_010953435.1 site-specific integrase -
RK21_RS29065 2960283..2960576 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RK21_RS13460 2960564..2960836 - 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
RK21_RS13465 2960961..2961206 - 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RK21_RS13470 2961468..2961740 + 273 WP_031299398.1 hypothetical protein -
RK21_RS13475 2961838..2962806 + 969 WP_031299399.1 DUF932 domain-containing protein -
RK21_RS13480 2962886..2963890 + 1005 WP_041506095.1 YqaJ viral recombinase family protein -
RK21_RS13485 2963983..2964933 + 951 WP_041506096.1 hypothetical protein -
RK21_RS13490 2964905..2965402 + 498 WP_041506097.1 DNA repair protein RadC -
RK21_RS30135 2965412..2965582 + 171 WP_017940310.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2943567..2960836 17269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T52222 WP_010953434.1 NZ_CP010359:c2960576-2960283 [Pseudomonas plecoglossicida]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T52222 NZ_CP010359:c2960576-2960283 [Pseudomonas plecoglossicida]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT52222 WP_010953433.1 NZ_CP010359:c2960836-2960564 [Pseudomonas plecoglossicida]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT52222 NZ_CP010359:c2960836-2960564 [Pseudomonas plecoglossicida]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References