Detailed information of TA system TA052221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2915321..2915837
• Replicon: chromosome
• Accession: NZ_CP010359
• Organism: Pseudomonas plecoglossicida strain NyZ12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F8G1E7
• Locus tag: RK21_RS13235
• Protein ID: WP_003259987.1
• Coordinates: 2915321..2915602 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F8G1E6
• Locus tag: RK21_RS13240
• Protein ID: WP_013972043.1
• Coordinates: 2915592..2915837 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK21_RS13215	2911084..2912325	-	1242	WP_013972047.1	Zn-dependent hydrolase	-
RK21_RS13220	2912356..2913660	-	1305	WP_013972046.1	MHS family MFS transporter	-
RK21_RS13225	2913890..2914798	+	909	WP_013972045.1	LysR family transcriptional regulator	-
RK21_RS13230	2914887..2915282	+	396	WP_023662326.1	hypothetical protein	-
RK21_RS13235	2915321..2915602	-	282	WP_003259987.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RK21_RS13240	2915592..2915837	-	246	WP_013972043.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RK21_RS13245	2916081..2917187	-	1107	WP_031325095.1	alkene reductase	-
RK21_RS13250	2917218..2918411	-	1194	WP_023662327.1	MFS transporter	-
RK21_RS13255	2918774..2919760	+	987	WP_013972040.1	zinc-binding dehydrogenase	-
RK21_RS13260	2919868..2920410	+	543	WP_013972039.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-76)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10909.78 Da
• Isoelectric Point: 10.7594

>T52221 WP_003259987.1 NZ_CP010359:c2915602-2915321 [Pseudomonas plecoglossicida]
MTYKLEFLPSALKEWGKLGHTVREQIKKKLAERLQSPKVQADALRDLPNHYKIKLKASGYRLVYRVEDERIVVVVVSVGK
RERSEVYRSAQKR

Nucleotide

• Length: 282 bp

>T52221 NZ_CP010359:c2915602-2915321 [Pseudomonas plecoglossicida]
ATGACCTATAAACTCGAATTCCTGCCTTCGGCACTGAAAGAGTGGGGCAAGCTAGGCCACACCGTGCGCGAACAGATCAA
GAAAAAACTCGCCGAGCGCCTGCAGTCACCCAAGGTACAGGCCGACGCGCTGCGTGACCTGCCGAACCACTACAAAATCA
AGCTCAAGGCCTCTGGATATCGCCTCGTCTATCGAGTCGAGGACGAGCGGATCGTTGTAGTGGTGGTATCGGTTGGCAAA
CGCGAGCGTAGCGAGGTGTATCGATCCGCTCAGAAGCGGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8779.21 Da
• Isoelectric Point: 4.3611

>AT52221 WP_013972043.1 NZ_CP010359:c2915837-2915592 [Pseudomonas plecoglossicida]
MQNIFADVAVSVSELKKNPSAVMTGAAGMPVAVLNHNRVMGYMVPAELYEAMMERLEDLELSELAKSRLGEKGVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT52221 NZ_CP010359:c2915837-2915592 [Pseudomonas plecoglossicida]
ATGCAAAACATATTCGCTGACGTGGCCGTAAGCGTGTCGGAACTGAAAAAGAACCCATCCGCGGTGATGACCGGCGCTGC
GGGTATGCCCGTCGCCGTGCTCAATCACAACCGCGTGATGGGTTACATGGTGCCGGCCGAACTGTACGAGGCCATGATGG
AACGCTTGGAAGATCTCGAATTGAGCGAACTGGCCAAGTCGAGGTTGGGTGAAAAAGGCGTACCGGTATCCCTGGATGAC
CTATAA

Structures

Toxin

• AlphaFold DB: F8G1E7

Antitoxin

• AlphaFold DB: F8G1E6