Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 7831..8359 Replicon plasmid pXBB1-5
Accession NZ_CP010356
Organism Acinetobacter johnsonii XBB1

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag EHS42_RS19535 Protein ID WP_000221358.1
Coordinates 8066..8359 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag EHS42_RS19530 Protein ID WP_000246756.1
Coordinates 7831..8076 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS42_RS19505 3775..4536 + 762 WP_058952642.1 hypothetical protein -
EHS42_RS19510 4584..4898 + 315 WP_058952643.1 hypothetical protein -
EHS42_RS19515 5133..5675 - 543 WP_005176773.1 cysteine hydrolase -
EHS42_RS19520 5760..6644 - 885 WP_004733158.1 MBL fold metallo-hydrolase -
EHS42_RS19525 6777..7748 + 972 WP_058952644.1 helix-turn-helix domain-containing protein -
EHS42_RS19530 7831..8076 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EHS42_RS19535 8066..8359 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHS42_RS19540 8410..8913 - 504 WP_058952645.1 hypothetical protein -
EHS42_RS19550 9661..9846 - 186 WP_058952646.1 hypothetical protein -
EHS42_RS19555 10103..10417 + 315 WP_058952647.1 hypothetical protein -
EHS42_RS19560 10522..10905 + 384 WP_058951668.1 IS66 family insertion sequence hypothetical protein -
EHS42_RS19565 10848..11237 + 390 WP_101598934.1 IS66 family insertion sequence element accessory protein TnpB -
EHS42_RS19570 11312..12936 + 1625 Protein_15 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..13940 13940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T52219 WP_000221358.1 NZ_CP010356:8066-8359 [Acinetobacter johnsonii XBB1]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T52219 NZ_CP010356:8066-8359 [Acinetobacter johnsonii XBB1]
ATGACTTATAAGCTTTTACGTCACAAAGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGGGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTATATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT52219 WP_000246756.1 NZ_CP010356:7831-8076 [Acinetobacter johnsonii XBB1]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT52219 NZ_CP010356:7831-8076 [Acinetobacter johnsonii XBB1]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAACGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References