Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 7831..8359 | Replicon | plasmid pXBB1-5 |
Accession | NZ_CP010356 | ||
Organism | Acinetobacter johnsonii XBB1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | N9N871 |
Locus tag | EHS42_RS19535 | Protein ID | WP_000221358.1 |
Coordinates | 8066..8359 (+) | Length | 98 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | N9B5Q7 |
Locus tag | EHS42_RS19530 | Protein ID | WP_000246756.1 |
Coordinates | 7831..8076 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EHS42_RS19505 | 3775..4536 | + | 762 | WP_058952642.1 | hypothetical protein | - |
EHS42_RS19510 | 4584..4898 | + | 315 | WP_058952643.1 | hypothetical protein | - |
EHS42_RS19515 | 5133..5675 | - | 543 | WP_005176773.1 | cysteine hydrolase | - |
EHS42_RS19520 | 5760..6644 | - | 885 | WP_004733158.1 | MBL fold metallo-hydrolase | - |
EHS42_RS19525 | 6777..7748 | + | 972 | WP_058952644.1 | helix-turn-helix domain-containing protein | - |
EHS42_RS19530 | 7831..8076 | + | 246 | WP_000246756.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
EHS42_RS19535 | 8066..8359 | + | 294 | WP_000221358.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EHS42_RS19540 | 8410..8913 | - | 504 | WP_058952645.1 | hypothetical protein | - |
EHS42_RS19550 | 9661..9846 | - | 186 | WP_058952646.1 | hypothetical protein | - |
EHS42_RS19555 | 10103..10417 | + | 315 | WP_058952647.1 | hypothetical protein | - |
EHS42_RS19560 | 10522..10905 | + | 384 | WP_058951668.1 | IS66 family insertion sequence hypothetical protein | - |
EHS42_RS19565 | 10848..11237 | + | 390 | WP_101598934.1 | IS66 family insertion sequence element accessory protein TnpB | - |
EHS42_RS19570 | 11312..12936 | + | 1625 | Protein_15 | IS66 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..13940 | 13940 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11292.52 Da Isoelectric Point: 10.4753
>T52219 WP_000221358.1 NZ_CP010356:8066-8359 [Acinetobacter johnsonii XBB1]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T52219 NZ_CP010356:8066-8359 [Acinetobacter johnsonii XBB1]
ATGACTTATAAGCTTTTACGTCACAAAGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGGGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTATATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA
ATGACTTATAAGCTTTTACGTCACAAAGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGGGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTATATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9235.61 Da Isoelectric Point: 4.3142
>AT52219 WP_000246756.1 NZ_CP010356:7831-8076 [Acinetobacter johnsonii XBB1]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
Download Length: 246 bp
>AT52219 NZ_CP010356:7831-8076 [Acinetobacter johnsonii XBB1]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAACGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAACGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6A1RKP4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | N9B5Q7 |