Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3694..4282 Replicon plasmid pXBB1-9
Accession NZ_CP010351
Organism Acinetobacter johnsonii XBB1

Toxin (Protein)


Gene name relE Uniprot ID N9CKJ9
Locus tag EHS42_RS17220 Protein ID WP_004647749.1
Coordinates 3986..4282 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EHS42_RS17215 Protein ID WP_004969304.1
Coordinates 3694..3984 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS42_RS17195 182..391 + 210 WP_004976362.1 hypothetical protein -
EHS42_RS17200 641..2095 + 1455 WP_026438532.1 SulP family inorganic anion transporter -
EHS42_RS17210 2272..3597 + 1326 WP_020846983.1 ISNCY family transposase -
EHS42_RS17215 3694..3984 - 291 WP_004969304.1 putative addiction module antidote protein Antitoxin
EHS42_RS17220 3986..4282 - 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHS42_RS17225 4717..5391 - 675 WP_058952551.1 hypothetical protein -
EHS42_RS17230 5519..5800 - 282 WP_058952552.1 hypothetical protein -
EHS42_RS17240 6105..6809 - 705 WP_001067790.1 IS6-like element IS1008 family transposase -
EHS42_RS17245 7049..7909 + 861 Protein_8 nucleotidyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3'')-Ib / aph(6)-Id / tet(Y) / ARR-3 / qacE / sul1 / blaPER-1 / aph(3')-VIa / aac(3)-IId / cmlB1 / mph(E) / msr(E) / blaOXA-58 - 1..398857 398857
- inside IScluster/Tn - - 2260..14829 12569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11584.25 Da        Isoelectric Point: 5.8801

>T52213 WP_004647749.1 NZ_CP010351:c4282-3986 [Acinetobacter johnsonii XBB1]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Download         Length: 297 bp

>T52213 NZ_CP010351:c4282-3986 [Acinetobacter johnsonii XBB1]
ATGATTGAAATTAAACGTCTTCCAGAATTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGTATCCGCCTGAA
TCGTCGATTAGATAAGGTTCAACGTGGAAACTGGGGAGACATTAAACCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAACATGGTGACGTTGTGATTGTAATGCTTGGTGGTGGAGATAAATCA
ACTCAACAACAAGACATCGATCGGGCAGTCAAACTATCGAAAACATTGGAGGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10524.19 Da        Isoelectric Point: 5.1133

>AT52213 WP_004969304.1 NZ_CP010351:c3984-3694 [Acinetobacter johnsonii XBB1]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHA

Download         Length: 291 bp

>AT52213 NZ_CP010351:c3984-3694 [Acinetobacter johnsonii XBB1]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCGCTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
TATGGTTCTTGAAGAAAATGATCCAGCTGAATTAGCCCATGCACTTGGTGTTATTGCTAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGGCGTGAAGCACTCTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTAGTAAATGCTTTAGGCTTAAAGCTCACAGTACAACACGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References