52212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 679505..680154 Replicon chromosome
Accession NZ_CP010350
Organism Acinetobacter johnsonii XBB1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U3RPE6
Locus tag EHS42_RS03400 Protein ID WP_010327421.1
Coordinates 679735..680154 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0U3RE63
Locus tag EHS42_RS03395 Protein ID WP_010327422.1
Coordinates 679505..679735 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS42_RS03375 674598..675320 - 723 WP_010327426.1 GcvT-like aminomethyltransferase -
EHS42_RS03380 675582..678188 + 2607 WP_010327425.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
EHS42_RS03385 678268..678489 + 222 WP_010327424.1 hypothetical protein -
EHS42_RS03390 678494..679432 + 939 WP_010327423.1 hypothetical protein -
EHS42_RS03395 679505..679735 + 231 WP_010327422.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EHS42_RS03400 679735..680154 + 420 WP_010327421.1 type II toxin-antitoxin system VapC family toxin Toxin
EHS42_RS03405 680285..680428 + 144 WP_004695201.1 zinc ribbon-containing protein -
EHS42_RS03410 680547..681122 + 576 WP_010327420.1 DUF4126 domain-containing protein -
EHS42_RS03415 681354..681560 + 207 WP_004695205.1 hypothetical protein -
EHS42_RS03420 681642..681995 - 354 WP_010327419.1 hypothetical protein -
EHS42_RS03425 682208..682906 + 699 WP_010327418.1 hypothetical protein -
EHS42_RS03430 683013..683285 + 273 WP_010327417.1 hypothetical protein -
EHS42_RS03435 683875..684270 + 396 WP_010327416.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16150.51 Da        Isoelectric Point: 6.2193

>T52212 WP_010327421.1 NZ_CP010350:679735-680154 [Acinetobacter johnsonii XBB1]
MQTQYLLDTNICIYIIKHQPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQQKEKALKVIDELTSMIQVVELDEYVA
DHYAQIRQDLSSKGQIIGANDLWLAAHARANNWVMVTNNEKEFLRVDGLQIENWVTNTL

Download         Length: 420 bp

>T52212 NZ_CP010350:679735-680154 [Acinetobacter johnsonii XBB1]
ATGCAGACACAATATTTATTGGATACGAATATTTGTATCTACATCATCAAACATCAACCTGAAATTGTCCGTCAGCATTT
TGAAAAACATCTCCCACATCGAAATATTTTAATTTCAGTCATTACTTTGGGGGAGTTGCGTTTTGGTGCAGAGAAAAGTC
AGCAAAAAGAAAAAGCCCTTAAAGTGATAGATGAATTAACCTCAATGATTCAAGTGGTTGAGTTAGATGAATATGTCGCT
GATCACTATGCGCAAATACGCCAAGACCTTTCATCTAAAGGGCAGATTATTGGTGCGAATGATTTGTGGCTTGCCGCGCA
TGCACGTGCGAATAATTGGGTGATGGTGACCAATAATGAAAAAGAATTTTTGCGTGTCGATGGATTGCAGATCGAAAATT
GGGTGACTAACACCTTGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9023.27 Da        Isoelectric Point: 4.6936

>AT52212 WP_010327422.1 NZ_CP010350:679505-679735 [Acinetobacter johnsonii XBB1]
MTTAKVFMTGRSQAVRLPKEFRFEGTEVEIFRRGDDVILREKPVTVDRLFKVLAQMPNDFYAEERVDEPPQEREEF

Download         Length: 231 bp

>AT52212 NZ_CP010350:679505-679735 [Acinetobacter johnsonii XBB1]
ATGACTACCGCAAAAGTTTTTATGACTGGTCGAAGCCAAGCTGTTCGCTTACCCAAAGAATTTCGCTTTGAAGGTACAGA
AGTCGAAATTTTCCGTCGTGGCGATGACGTGATTCTGCGTGAAAAGCCAGTCACCGTAGATCGGTTATTTAAAGTATTAG
CGCAAATGCCGAATGACTTTTATGCAGAAGAAAGAGTGGATGAACCACCACAGGAACGAGAAGAGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3RPE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3RE63

References