Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 429944..430593 Replicon chromosome
Accession NZ_CP010350
Organism Acinetobacter johnsonii XBB1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U3RS34
Locus tag EHS42_RS02150 Protein ID WP_010327588.1
Coordinates 430207..430593 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0SF65
Locus tag EHS42_RS02145 Protein ID WP_005401275.1
Coordinates 429944..430201 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS42_RS02125 425563..425928 + 366 WP_004691290.1 50S ribosomal protein L17 -
EHS42_RS02130 426124..427614 + 1491 WP_010327591.1 NAD(P)/FAD-dependent oxidoreductase -
EHS42_RS02135 427753..428544 + 792 WP_010327590.1 alpha/beta hydrolase -
EHS42_RS02140 428579..429751 - 1173 WP_010327589.1 acyl-CoA dehydrogenase family protein -
EHS42_RS02145 429944..430201 + 258 WP_005401275.1 succinate dehydrogenase assembly factor 2 Antitoxin
EHS42_RS02150 430207..430593 + 387 WP_010327588.1 hypothetical protein Toxin
EHS42_RS02155 431113..432150 + 1038 WP_010327587.1 hypothetical protein -
EHS42_RS02160 432222..432794 + 573 WP_010327586.1 rhombosortase -
EHS42_RS02165 432977..435259 + 2283 WP_010327585.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(5-127)

Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 15505.52 Da        Isoelectric Point: 10.3370

>T52211 WP_010327588.1 NZ_CP010350:430207-430593 [Acinetobacter johnsonii XBB1]
MDNRHFQLKPSRLAYVFQLSIYAILMFVLYQLLPLWLWLIALVAGFILYLFFLRGPQHFQLQYLDGRDWSLSLQKHTNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPLTQWKALKILTKMQ

Download         Length: 387 bp

>T52211 NZ_CP010350:430207-430593 [Acinetobacter johnsonii XBB1]
ATGGATAATCGTCATTTTCAACTGAAACCCAGCCGTTTGGCTTATGTATTTCAGTTGTCAATCTATGCCATCTTAATGTT
TGTACTGTATCAGCTATTGCCTTTGTGGTTATGGCTGATTGCTTTGGTTGCAGGTTTTATCTTATATCTGTTTTTTCTAC
GTGGACCGCAACACTTTCAATTACAGTATTTGGATGGCCGAGATTGGTCCTTGTCACTTCAGAAACATACCAATGTGCAA
CGCGTTCAAATCAGCCATATTGTGGATCATCGTGCGTATATCGTGATCTATTTTCAGCATTTCCGTGCCAAACCGATGTT
GGTCTGGTGTGATCAACTGCCGCTGACGCAGTGGAAAGCGTTGAAAATACTCACCAAAATGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10162.66 Da        Isoelectric Point: 4.7091

>AT52211 WP_005401275.1 NZ_CP010350:429944-430201 [Acinetobacter johnsonii XBB1]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPHPEMKTLIQKLK
HYVHG

Download         Length: 258 bp

>AT52211 NZ_CP010350:429944-430201 [Acinetobacter johnsonii XBB1]
ATGACTGAAGAAATGAGCTTGGAAGAGCGTAAAGTAATCTATCGTGCACGTCGTGGTTTAAAAGAAATTGATGTGTACTT
TGACCCTTATGTGAAAAATTATTATCTTCAGGCGGATCCTGCGGAAAAGGCCATGTTTGCGGCATTGGTTGAACAAGAAG
ACCCTGATTTATTGGACTGGTTCATGGAAGTTTCTGAACCACCACACCCTGAAATGAAAACCTTGATCCAAAAGTTAAAG
CATTATGTACATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3RS34

Antitoxin

Source ID Structure
AlphaFold DB A0A0U2ZZN5

References