Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3758594..3759123 | Replicon | chromosome |
| Accession | NZ_CP010339 | ||
| Organism | Mycobacterium tuberculosis strain 22103 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | RN14_RS17640 | Protein ID | WP_003417760.1 |
| Coordinates | 3758866..3759123 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | RN14_RS17635 | Protein ID | WP_003417757.1 |
| Coordinates | 3758594..3758869 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RN14_RS23150 (RN14_3560) | 3755168..3755857 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| RN14_RS23155 (RN14_3561) | 3756044..3756415 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| RN14_RS23160 | 3756313..3756531 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| RN14_RS23165 (RN14_3562) | 3756558..3756818 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| RN14_RS17620 (RN14_3563) | 3756933..3757322 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| RN14_RS17625 (RN14_3564) | 3757336..3757629 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| RN14_RS17630 (RN14_3565) | 3757626..3758470 | - | 845 | Protein_3500 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| RN14_RS17635 (RN14_3566) | 3758594..3758869 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| RN14_RS17640 (RN14_3567) | 3758866..3759123 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| RN14_RS17645 (RN14_3568) | 3759165..3760355 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| RN14_RS17650 (RN14_3569) | 3760472..3760840 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| RN14_RS17655 (RN14_3570) | 3760788..3761387 | - | 600 | WP_060811872.1 | pentapeptide repeat protein MfpA | - |
| RN14_RS17660 (RN14_3571) | 3761394..3761975 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| RN14_RS17665 (RN14_3572) | 3761956..3762324 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| RN14_RS17670 (RN14_3573) | 3762302..3762694 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T52170 WP_003417760.1 NZ_CP010339:3758866-3759123 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T52170 NZ_CP010339:3758866-3759123 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT52170 WP_003417757.1 NZ_CP010339:3758594-3758869 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT52170 NZ_CP010339:3758594-3758869 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|