52166

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3175425..3175973 Replicon chromosome
Accession NZ_CP010339
Organism Mycobacterium tuberculosis strain 22103

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag RN14_RS15030 Protein ID WP_003414602.1
Coordinates 3175710..3175973 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag RN14_RS15025 Protein ID WP_003414599.1
Coordinates 3175425..3175706 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN14_RS15000 (RN14_3035) 3171049..3171906 - 858 WP_003899513.1 type I methionyl aminopeptidase -
RN14_RS15005 (RN14_3036) 3171948..3172532 - 585 WP_003899514.1 DUF1707 domain-containing protein -
RN14_RS15010 3172636..3172884 + 249 WP_003913411.1 antitoxin VapB23 -
RN14_RS15015 (RN14_3037) 3172881..3173261 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
RN14_RS15020 (RN14_3038) 3173343..3175154 - 1812 WP_003414596.1 penicillin-binding protein -
RN14_RS15025 (RN14_3039) 3175425..3175706 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
RN14_RS15030 (RN14_3040) 3175710..3175973 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RN14_RS15035 (RN14_3041) 3176346..3177200 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
RN14_RS15040 (RN14_3042) 3177256..3178419 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
RN14_RS15045 (RN14_3043) 3178436..3179650 - 1215 WP_003899518.1 zinc metalloprotease Rip -
RN14_RS15050 (RN14_3044) 3179658..3180899 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T52166 WP_003414602.1 NZ_CP010339:3175710-3175973 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T52166 NZ_CP010339:3175710-3175973 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT52166 WP_003414599.1 NZ_CP010339:3175425-3175706 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT52166 NZ_CP010339:3175425-3175706 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWP8

References