Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3068692..3069379 | Replicon | chromosome |
| Accession | NZ_CP010339 | ||
| Organism | Mycobacterium tuberculosis strain 22103 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TF65 |
| Locus tag | RN14_RS14470 | Protein ID | WP_003414064.1 |
| Coordinates | 3068984..3069379 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | RN14_RS14465 | Protein ID | WP_003414061.1 |
| Coordinates | 3068692..3068958 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RN14_RS14440 (RN14_2922) | 3064331..3065233 | - | 903 | WP_031647842.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| RN14_RS14445 (RN14_2923) | 3065302..3066054 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| RN14_RS14450 | 3066298..3066573 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| RN14_RS14455 (RN14_2924) | 3066570..3068192 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| RN14_RS14460 (RN14_2925) | 3068279..3068695 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | - |
| RN14_RS14465 (RN14_2926) | 3068692..3068958 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| RN14_RS14470 (RN14_2927) | 3068984..3069379 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| RN14_RS14475 (RN14_2928) | 3069376..3069645 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| RN14_RS14480 (RN14_2929) | 3069655..3070749 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| RN14_RS14485 (RN14_2930) | 3070746..3071165 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| RN14_RS23080 | 3071164..3071238 | + | 75 | Protein_2877 | hypothetical protein | - |
| RN14_RS14490 (RN14_2931) | 3071239..3071718 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| RN14_RS14495 (RN14_2932) | 3071789..3072589 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| RN14_RS14500 (RN14_2933) | 3072745..3073482 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14340.04 Da Isoelectric Point: 4.7145
>T52162 WP_003414064.1 NZ_CP010339:c3069379-3068984 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
Download Length: 396 bp
>T52162 NZ_CP010339:c3069379-3068984 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT52162 WP_003414061.1 NZ_CP010339:c3068958-3068692 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT52162 NZ_CP010339:c3068958-3068692 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|