Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2929606..2930320 Replicon chromosome
Accession NZ_CP010339
Organism Mycobacterium tuberculosis strain 22103

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag RN14_RS13660 Protein ID WP_003413460.1
Coordinates 2929880..2930320 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag RN14_RS13655 Protein ID WP_003413456.1
Coordinates 2929606..2929893 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN14_RS13620 (RN14_2759) 2925028..2925273 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
RN14_RS13625 (RN14_2760) 2925270..2925674 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
RN14_RS13630 (RN14_2761) 2925891..2926511 + 621 WP_003413441.1 DUF4178 domain-containing protein -
RN14_RS13635 (RN14_2762) 2926522..2927016 + 495 WP_003413444.1 DUF2617 family protein -
RN14_RS13640 (RN14_2763) 2927013..2927444 + 432 WP_003899390.1 DUF4247 domain-containing protein -
RN14_RS13645 (RN14_2764) 2927469..2927927 + 459 WP_003413451.1 DUF350 domain-containing protein -
RN14_RS13650 (RN14_2765) 2927924..2929495 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
RN14_RS13655 (RN14_2766) 2929606..2929893 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
RN14_RS13660 (RN14_2767) 2929880..2930320 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
RN14_RS13665 (RN14_2768) 2930341..2931096 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
RN14_RS13670 (RN14_2769) 2931229..2931825 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
RN14_RS13675 (RN14_2770) 2931833..2932678 - 846 WP_003413466.1 acyl-CoA thioesterase II -
RN14_RS13680 (RN14_2771) 2932707..2933606 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
RN14_RS13685 (RN14_2772) 2933734..2934408 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T52159 WP_003413460.1 NZ_CP010339:2929880-2930320 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T52159 NZ_CP010339:2929880-2930320 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT52159 WP_003413456.1 NZ_CP010339:2929606-2929893 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT52159 NZ_CP010339:2929606-2929893 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References