Detailed information of TA system TA052153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2404066..2404595
• Replicon: chromosome
• Accession: NZ_CP010339
• Organism: Mycobacterium tuberculosis strain 22103

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: RN14_RS11195
• Protein ID: WP_003411124.1
• Coordinates: 2404066..2404383 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: RN14_RS11200
• Protein ID: WP_003411127.1
• Coordinates: 2404380..2404595 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RN14_RS11165 (RN14_2279)	2399089..2400165	+	1077	WP_003411110.1	hypothetical protein	-
RN14_RS11170 (RN14_2280)	2400162..2400443	+	282	WP_003411112.1	DUF5703 family protein	-
RN14_RS11175 (RN14_2281)	2400479..2401552	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
RN14_RS11180 (RN14_2282)	2401557..2402087	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
RN14_RS11185 (RN14_2283)	2402135..2403481	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
RN14_RS11195 (RN14_2284)	2404066..2404383	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RN14_RS11200 (RN14_2285)	2404380..2404595	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
RN14_RS11205 (RN14_2286)	2404850..2405908	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
RN14_RS11210 (RN14_2287)	2406038..2406394	-	357	WP_003411130.1	hypothetical protein	-
RN14_RS11215 (RN14_2288)	2406489..2407271	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
RN14_RS11220 (RN14_2289)	2407539..2407829	-	291	WP_003900476.1	YggT family protein	-
RN14_RS11225 (RN14_2290)	2407991..2408647	-	657	WP_003411133.1	cell division protein SepF	-
RN14_RS11230 (RN14_2291)	2408713..2409489	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T52153 WP_003411124.1 NZ_CP010339:c2404383-2404066 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T52153 NZ_CP010339:c2404383-2404066 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT52153 WP_003411127.1 NZ_CP010339:c2404595-2404380 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT52153 NZ_CP010339:c2404595-2404380 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4