Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2404066..2404595 Replicon chromosome
Accession NZ_CP010339
Organism Mycobacterium tuberculosis strain 22103

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag RN14_RS11195 Protein ID WP_003411124.1
Coordinates 2404066..2404383 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag RN14_RS11200 Protein ID WP_003411127.1
Coordinates 2404380..2404595 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN14_RS11165 (RN14_2279) 2399089..2400165 + 1077 WP_003411110.1 hypothetical protein -
RN14_RS11170 (RN14_2280) 2400162..2400443 + 282 WP_003411112.1 DUF5703 family protein -
RN14_RS11175 (RN14_2281) 2400479..2401552 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
RN14_RS11180 (RN14_2282) 2401557..2402087 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
RN14_RS11185 (RN14_2283) 2402135..2403481 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
RN14_RS11195 (RN14_2284) 2404066..2404383 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RN14_RS11200 (RN14_2285) 2404380..2404595 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
RN14_RS11205 (RN14_2286) 2404850..2405908 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
RN14_RS11210 (RN14_2287) 2406038..2406394 - 357 WP_003411130.1 hypothetical protein -
RN14_RS11215 (RN14_2288) 2406489..2407271 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
RN14_RS11220 (RN14_2289) 2407539..2407829 - 291 WP_003900476.1 YggT family protein -
RN14_RS11225 (RN14_2290) 2407991..2408647 - 657 WP_003411133.1 cell division protein SepF -
RN14_RS11230 (RN14_2291) 2408713..2409489 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T52153 WP_003411124.1 NZ_CP010339:c2404383-2404066 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T52153 NZ_CP010339:c2404383-2404066 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT52153 WP_003411127.1 NZ_CP010339:c2404595-2404380 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT52153 NZ_CP010339:c2404595-2404380 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References