Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2201751..2202295 | Replicon | chromosome |
| Accession | NZ_CP010339 | ||
| Organism | Mycobacterium tuberculosis strain 22103 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | RN14_RS10195 | Protein ID | WP_003409896.1 |
| Coordinates | 2201751..2202047 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | RN14_RS10200 | Protein ID | WP_003409899.1 |
| Coordinates | 2202044..2202295 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RN14_RS10140 (RN14_2073) | 2196784..2197134 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| RN14_RS10145 (RN14_2074) | 2197145..2198047 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| RN14_RS10150 (RN14_2075) | 2198068..2198259 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| RN14_RS10155 (RN14_2076) | 2198260..2198556 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| RN14_RS10160 (RN14_2077) | 2198796..2199011 | + | 216 | WP_003409878.1 | antitoxin | - |
| RN14_RS10165 (RN14_2078) | 2199008..2199319 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| RN14_RS22350 | 2199293..2199814 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| RN14_RS10175 (RN14_2080) | 2199789..2200166 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| RN14_RS10180 (RN14_2081) | 2200208..2200657 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| RN14_RS10185 (RN14_2082) | 2200654..2201199 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| RN14_RS10190 (RN14_2083) | 2201088..2201702 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| RN14_RS10195 (RN14_2084) | 2201751..2202047 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| RN14_RS10200 (RN14_2085) | 2202044..2202295 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| RN14_RS10205 (RN14_2086) | 2202282..2202776 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| RN14_RS10210 (RN14_2088) | 2202936..2203343 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| RN14_RS10215 (RN14_2089) | 2203347..2203619 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| RN14_RS10220 (RN14_2090) | 2203652..2204872 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| RN14_RS10230 (RN14_2092) | 2205771..2206568 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T52145 WP_003409896.1 NZ_CP010339:c2202047-2201751 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T52145 NZ_CP010339:c2202047-2201751 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT52145 WP_003409899.1 NZ_CP010339:c2202295-2202044 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT52145 NZ_CP010339:c2202295-2202044 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |