Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 1960539..1960999 | Replicon | chromosome |
Accession | NZ_CP010339 | ||
Organism | Mycobacterium tuberculosis strain 22103 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TKL9 |
Locus tag | RN14_RS09105 | Protein ID | WP_003898996.1 |
Coordinates | 1960751..1960999 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ30 |
Locus tag | RN14_RS09100 | Protein ID | WP_003408528.1 |
Coordinates | 1960539..1960751 (+) | Length | 71 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RN14_RS09085 (RN14_1850) | 1957017..1958204 | - | 1188 | WP_003898992.1 | nitrate transporter NarK | - |
RN14_RS09090 (RN14_1851) | 1958491..1958775 | + | 285 | WP_003408522.1 | DUF1876 domain-containing protein | - |
RN14_RS09095 (RN14_1852) | 1958789..1960471 | - | 1683 | WP_003898994.1 | SulP family inorganic anion transporter | - |
RN14_RS09100 (RN14_1853) | 1960539..1960751 | + | 213 | WP_003408528.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
RN14_RS09105 (RN14_1854) | 1960751..1960999 | + | 249 | WP_003898996.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
RN14_RS09110 (RN14_1855) | 1961007..1961744 | + | 738 | WP_003898997.1 | hypothetical protein | - |
RN14_RS09115 (RN14_1856) | 1961838..1963538 | + | 1701 | WP_003898998.1 | serine/threonine protein kinase PknE | - |
RN14_RS09120 (RN14_1857) | 1963823..1964224 | - | 402 | WP_003408538.1 | hypothetical protein | - |
RN14_RS09125 (RN14_1858) | 1964214..1964825 | - | 612 | WP_003898999.1 | isopentenyl-diphosphate Delta-isomerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 8884.14 Da Isoelectric Point: 4.1074
>T52142 WP_003898996.1 NZ_CP010339:1960751-1960999 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
Download Length: 249 bp
>T52142 NZ_CP010339:1960751-1960999 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
Antitoxin
Download Length: 71 a.a. Molecular weight: 7607.80 Da Isoelectric Point: 9.3146
>AT52142 WP_003408528.1 NZ_CP010339:1960539-1960751 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
Download Length: 213 bp
>AT52142 NZ_CP010339:1960539-1960751 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TKL9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CFE8 |