52138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1576013..1576668 Replicon chromosome
Accession NZ_CP010339
Organism Mycobacterium tuberculosis strain 22103

Toxin (Protein)


Gene name vapC Uniprot ID A0A654ZI33
Locus tag RN14_RS07390 Protein ID WP_031581039.1
Coordinates 1576013..1576414 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag RN14_RS07395 Protein ID WP_003407272.1
Coordinates 1576411..1576668 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN14_RS07375 (RN14_1496) 1571486..1572871 - 1386 WP_003407260.1 cytochrome P450 -
RN14_RS07380 (RN14_1497) 1572949..1573983 + 1035 WP_003407264.1 AraC family transcriptional regulator -
RN14_RS07385 1574029..1575758 - 1730 Protein_1464 PE family protein -
RN14_RS07390 (RN14_1500) 1576013..1576414 - 402 WP_031581039.1 type II toxin-antitoxin system VapC family toxin Toxin
RN14_RS07395 (RN14_1501) 1576411..1576668 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
RN14_RS07400 (RN14_1502) 1576751..1577710 - 960 WP_003407276.1 alpha/beta hydrolase -
RN14_RS07405 (RN14_1503) 1577735..1578697 - 963 WP_003407279.1 alpha/beta hydrolase -
RN14_RS07410 (RN14_1504) 1578696..1579433 + 738 WP_031647000.1 lysoplasmalogenase -
RN14_RS07415 (RN14_1505) 1579514..1581481 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14982.46 Da        Isoelectric Point: 11.1839

>T52138 WP_031581039.1 NZ_CP010339:c1576414-1576013 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPWA

Download         Length: 402 bp

>T52138 NZ_CP010339:c1576414-1576013 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGTGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT52138 WP_003407272.1 NZ_CP010339:c1576668-1576411 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT52138 NZ_CP010339:c1576668-1576411 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654ZI33

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References