Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 713823..714448 Replicon chromosome
Accession NZ_CP010339
Organism Mycobacterium tuberculosis strain 22103

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag RN14_RS03225 Protein ID WP_003403218.1
Coordinates 714047..714448 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag RN14_RS03220 Protein ID WP_003403213.1
Coordinates 713823..714050 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN14_RS03190 (RN14_0658) 709002..709223 - 222 WP_003898525.1 DUF4926 domain-containing protein -
RN14_RS03195 (RN14_0659) 709365..709970 + 606 WP_003898526.1 hypothetical protein -
RN14_RS03200 (RN14_0660) 709989..712556 - 2568 WP_060811882.1 SEC-C metal-binding domain-containing protein -
RN14_RS03205 (RN14_0661) 712640..713389 + 750 WP_003898528.1 hypothetical protein -
RN14_RS03210 (RN14_0662) 713386..713628 + 243 WP_003403210.1 hypothetical protein -
RN14_RS03220 (RN14_0663) 713823..714050 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
RN14_RS03225 (RN14_0664) 714047..714448 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
RN14_RS22805 714577..714660 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
RN14_RS22810 714679..715760 + 1082 Protein_646 galactose-1-phosphate uridylyltransferase -
RN14_RS03235 (RN14_0667) 715757..716848 + 1092 WP_003906403.1 galactokinase -
RN14_RS03245 (RN14_0668) 717243..718307 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
RN14_RS03250 (RN14_0669) 718411..719358 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T52122 WP_003403218.1 NZ_CP010339:714047-714448 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T52122 NZ_CP010339:714047-714448 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT52122 WP_003403213.1 NZ_CP010339:713823-714050 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT52122 NZ_CP010339:713823-714050 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References