Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 706285..706928 Replicon chromosome
Accession NZ_CP010339
Organism Mycobacterium tuberculosis strain 22103

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag RN14_RS03170 Protein ID WP_003403187.1
Coordinates 706527..706928 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag RN14_RS03165 Protein ID WP_003403184.1
Coordinates 706285..706530 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN14_RS03130 (RN14_0647) 701565..702095 - 531 WP_003917320.1 two component system sensor kinase HK2 -
RN14_RS03135 (RN14_0648) 702079..702774 - 696 WP_003918099.1 two-component system response regulator TcrA -
RN14_RS03140 (RN14_0649) 702897..703208 + 312 WP_003403164.1 hypothetical protein -
RN14_RS03145 (RN14_0650) 703280..704230 + 951 WP_003900184.1 DUF1259 domain-containing protein -
RN14_RS03150 (RN14_0651) 704471..705055 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
RN14_RS03155 (RN14_0652) 705057..705767 + 711 Protein_631 IS607 family element RNA-guided endonuclease TnpB -
RN14_RS03160 (RN14_0653) 705770..706240 + 471 WP_003898523.1 hypothetical protein -
RN14_RS03165 (RN14_0654) 706285..706530 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RN14_RS03170 (RN14_0655) 706527..706928 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
RN14_RS22800 706919..707098 + 180 Protein_635 hypothetical protein -
RN14_RS21895 (RN14_0656) 707516..707713 - 198 WP_003403191.1 hypothetical protein -
RN14_RS03185 (RN14_0657) 707793..708950 - 1158 WP_003898524.1 hypothetical protein -
RN14_RS03190 (RN14_0658) 709002..709223 - 222 WP_003898525.1 DUF4926 domain-containing protein -
RN14_RS03195 (RN14_0659) 709365..709970 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T52121 WP_003403187.1 NZ_CP010339:706527-706928 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T52121 NZ_CP010339:706527-706928 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT52121 WP_003403184.1 NZ_CP010339:706285-706530 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT52121 NZ_CP010339:706285-706530 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References