Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 366798..367441 Replicon chromosome
Accession NZ_CP010339
Organism Mycobacterium tuberculosis strain 22103

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag RN14_RS01590 Protein ID WP_003401566.1
Coordinates 367016..367441 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag RN14_RS01585 Protein ID WP_003401563.1
Coordinates 366798..367019 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN14_RS01560 (RN14_0325) 361917..362720 - 804 WP_003401540.1 Stf0 family sulphotransferase -
RN14_RS01565 (RN14_0326) 362730..364127 - 1398 WP_003401544.1 sulfatase -
RN14_RS01570 (RN14_0327) 364306..366081 + 1776 WP_010886074.1 PE family protein -
RN14_RS01575 (RN14_0328) 366224..366451 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
RN14_RS01580 (RN14_0329) 366448..366750 + 303 WP_003401560.1 toxin-antitoxin system toxin -
RN14_RS01585 (RN14_0330) 366798..367019 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
RN14_RS01590 (RN14_0331) 367016..367441 + 426 WP_003401566.1 PIN domain nuclease Toxin
RN14_RS01595 (RN14_0332) 367576..368208 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
RN14_RS01600 (RN14_0333) 368205..369113 + 909 WP_003900117.1 protochlorophyllide reductase -
RN14_RS22770 369121..369711 - 591 WP_229298012.1 hypothetical protein -
RN14_RS22775 369704..369754 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T52115 WP_003401566.1 NZ_CP010339:367016-367441 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T52115 NZ_CP010339:367016-367441 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT52115 WP_003401563.1 NZ_CP010339:366798-367019 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT52115 NZ_CP010339:366798-367019 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References