Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3715627..3716301 Replicon chromosome
Accession NZ_CP010330
Organism Mycobacterium tuberculosis strain F28

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag RN05_RS17625 Protein ID WP_003417282.1
Coordinates 3715627..3716055 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag RN05_RS17630 Protein ID WP_003417286.1
Coordinates 3716059..3716301 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN05_RS17600 3711449..3711850 - 402 WP_003417264.1 cytidine deaminase -
RN05_RS17605 3711991..3712425 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
RN05_RS17610 3712422..3712856 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
RN05_RS17615 3712985..3714757 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
RN05_RS17620 3714757..3715548 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
RN05_RS17625 3715627..3716055 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
RN05_RS17630 3716059..3716301 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
RN05_RS17635 3716423..3717037 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
RN05_RS17640 3717034..3717699 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
RN05_RS17645 3717700..3718233 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
RN05_RS22985 3718230..3718382 - 153 WP_003916129.1 hypothetical protein -
RN05_RS17660 3718418..3719679 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T52108 WP_003417282.1 NZ_CP010330:c3716055-3715627 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T52108 NZ_CP010330:c3716055-3715627 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT52108 WP_003417286.1 NZ_CP010330:c3716301-3716059 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT52108 NZ_CP010330:c3716301-3716059 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References