Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2210638..2211182 Replicon chromosome
Accession NZ_CP010330
Organism Mycobacterium tuberculosis strain F28

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag RN05_RS10335 Protein ID WP_003409896.1
Coordinates 2210638..2210934 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag RN05_RS10340 Protein ID WP_003409899.1
Coordinates 2210931..2211182 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN05_RS10280 2205671..2206021 - 351 WP_003899096.1 hypothetical protein -
RN05_RS10285 2206032..2206934 - 903 WP_003899097.1 hypothetical protein -
RN05_RS10290 2206955..2207146 - 192 WP_003409876.1 hypothetical protein -
RN05_RS10295 2207147..2207443 - 297 WP_003409877.1 hypothetical protein -
RN05_RS10300 2207683..2207898 + 216 WP_003409878.1 antitoxin -
RN05_RS10305 2207895..2208206 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
RN05_RS22640 2208180..2208701 - 522 WP_003904745.1 hypothetical protein -
RN05_RS10315 2208676..2209053 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
RN05_RS10320 2209095..2209544 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
RN05_RS10325 2209541..2210086 + 546 WP_003409891.1 SecB-like chaperone -
RN05_RS10330 2209975..2210589 - 615 WP_003901296.1 hypothetical protein -
RN05_RS10335 2210638..2210934 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RN05_RS10340 2210931..2211182 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
RN05_RS10345 2211169..2211663 + 495 WP_003899099.1 hypothetical protein -
RN05_RS10350 2211823..2212230 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
RN05_RS10355 2212234..2212506 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RN05_RS10360 2212539..2213759 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
RN05_RS10370 2214658..2215455 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T52084 WP_003409896.1 NZ_CP010330:c2210934-2210638 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T52084 NZ_CP010330:c2210934-2210638 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT52084 WP_003409899.1 NZ_CP010330:c2211182-2210931 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT52084 NZ_CP010330:c2211182-2210931 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References