Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1201943..1203195 Replicon chromosome
Accession NZ_CP010319
Organism Streptococcus agalactiae strain GBS85147

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag GBS85147_RS06075 Protein ID WP_024439956.1
Coordinates 1201943..1202719 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag GBS85147_RS06080 Protein ID WP_053039148.1
Coordinates 1202719..1203195 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBS85147_RS06055 1197282..1197641 - 360 WP_000529540.1 hypothetical protein -
GBS85147_RS06065 1198070..1201153 - 3084 WP_024439955.1 DEAD/DEAH box helicase -
GBS85147_RS06070 1201150..1201959 - 810 WP_032460833.1 DUF1837 domain-containing protein -
GBS85147_RS06075 1201943..1202719 - 777 WP_024439956.1 zeta toxin family protein Toxin
GBS85147_RS06080 1202719..1203195 - 477 WP_053039148.1 helix-turn-helix domain-containing protein Antitoxin
GBS85147_RS06085 1203266..1203553 - 288 WP_024439957.1 hypothetical protein -
GBS85147_RS06090 1203597..1203986 - 390 WP_053039149.1 hypothetical protein -
GBS85147_RS06095 1203990..1204217 - 228 WP_024439959.1 hypothetical protein -
GBS85147_RS06100 1204271..1205359 - 1089 WP_053039150.1 toprim domain-containing protein -
GBS85147_RS06105 1205398..1206036 - 639 WP_017649760.1 hypothetical protein -
GBS85147_RS06110 1206190..1206765 - 576 WP_017649761.1 hypothetical protein -
GBS85147_RS06115 1206758..1207498 - 741 WP_024439961.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29422.14 Da        Isoelectric Point: 6.5044

>T52046 WP_024439956.1 NZ_CP010319:c1202719-1201943 [Streptococcus agalactiae]
MALADYHQDDFDFALKRTIRSLTRGKETSVNPNAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSYRSLHPNYLALQE
EYGKDSVDYTKGFAGKMAEHLVDELSKQGYHLLIEGTLRTAEVRRKTAQLLKSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKEHHDAIVEHLVDNLRELETDKLFDQIQIYQRDRRCAYDSETDKGSAADVLQECLFGKWSKVEEEMM
KVGQEQLREVGRRNEKDA

Download         Length: 777 bp

>T52046 NZ_CP010319:c1202719-1201943 [Streptococcus agalactiae]
ATGGCTCTGGCAGACTATCATCAAGATGACTTTGACTTTGCCTTAAAACGAACCATTCGTTCTTTAACTCGTGGCAAAGA
GACATCAGTTAACCCAAATGCAATTTTACTTGGCGGACAAAGCGGAGCAGGTAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTTCAAGGGAATATCGTCATTATAGACGGTGATAGTTATCGCTCTTTACACCCGAACTATCTAGCTTTACAAGAA
GAATACGGTAAAGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGCGGAACATCTTGTCGATGAACTCAGCAA
GCAAGGTTATCATTTATTAATTGAAGGAACCTTGAGAACGGCAGAAGTCCGACGAAAAACAGCTCAGTTATTGAAATCAA
GAGGCTATCAAGTCTCGTTAGCTTTGATAGCAACCAAACCTGAATTGTCCTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGCGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGCTATTGTAGAGCATTTAGTTGATAA
CTTACGAGAGTTAGAAACTGATAAACTCTTTGACCAGATTCAAATTTATCAAAGAGACAGACGTTGTGCCTATGATTCTG
AAACAGATAAAGGTTCAGCAGCCGATGTCCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTAGAGGAGGAGATGATG
AAGGTGGGACAGGAACAGTTGAGGGAAGTAGGTAGAAGGAATGAAAAAGATGCATAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18087.62 Da        Isoelectric Point: 4.5938

>AT52046 WP_053039148.1 NZ_CP010319:c1203195-1202719 [Streptococcus agalactiae]
MIGENIKSLRKTHDLTQPKFAKIVGISRNSLSRYENGTSSVTTELIDCICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLVLARHQVVA

Download         Length: 477 bp

>AT52046 NZ_CP010319:c1203195-1202719 [Streptococcus agalactiae]
ATGATTGGAGAGAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAAAATTCGCAAAGATTGTTGGAATTTC
ACGAAATAGCCTTAGCCGTTATGAAAATGGTACGAGTTCAGTCACAACAGAACTTATAGACTGCATTTGTCAGAAATTCA
ATGTTTCTTATGTTGATATTGTAGGAGAAGAGAAGATGTTAACACCAGTAGAAGATTATCAATTGACGCTAAAAATAGAA
GTCATCAAAGAGCGTGGCGCAGCGATTTTATCTCAACTATATCGCTATCAAGATAGTCAAGGAATCGCTTTTGACGATGA
GACCAATCCTTGGATTTTAATGAGTGATGACTTGTCAGACCTTATCAATACCAAGATTTACCTTGTTAATACGTTTGATG
AAGTGGAGCGTTACAATGGTTATTTGGATGGTATTGAGCGCATGTTGGTACTTGCTCGTCATCAGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References