Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 3292801..3293368 Replicon chromosome
Accession NZ_CP010311
Organism Geoalkalibacter subterraneus strain Red1

Toxin (Protein)


Gene name mazF Uniprot ID A0A0B5FHK1
Locus tag GSUB_RS15470 Protein ID WP_040201616.1
Coordinates 3292801..3293148 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0B5FJW6
Locus tag GSUB_RS15475 Protein ID WP_040201618.1
Coordinates 3293138..3293368 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSUB_RS15450 3288921..3290441 - 1521 WP_040201610.1 capsule assembly Wzi family protein -
GSUB_RS15455 3290635..3292056 + 1422 WP_040201612.1 MBL fold metallo-hydrolase -
GSUB_RS15460 3292192..3292413 + 222 WP_040201613.1 ribbon-helix-helix protein, CopG family -
GSUB_RS15465 3292391..3292645 + 255 WP_040201614.1 type II toxin-antitoxin system RelE/ParE family toxin -
GSUB_RS15470 3292801..3293148 - 348 WP_040201616.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GSUB_RS15475 3293138..3293368 - 231 WP_040201618.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
GSUB_RS15480 3293679..3295100 + 1422 WP_040201620.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase -
GSUB_RS15485 3295114..3296466 + 1353 WP_040201621.1 phosphomannomutase/phosphoglucomutase -
GSUB_RS15490 3296653..3296958 + 306 WP_040201622.1 hypothetical protein -
GSUB_RS15495 3297142..3297657 + 516 WP_040201624.1 hypothetical protein -
GSUB_RS15500 3297670..3298083 + 414 WP_040201625.1 archease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-109)

Antitoxin

PrlF antitoxin

(6-42)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12647.84 Da        Isoelectric Point: 9.9187

>T51987 WP_040201616.1 NZ_CP010311:c3293148-3292801 [Geoalkalibacter subterraneus]
MIYEAFDVVVVPFPFTDRATTKRRPALILSDAAIFNRPVGQAVMAMITSARNSDWPLDVEIEDLDAAGLPAPSIVRMKLF
TLDEKLVLRKAGALVGADRGRISSVLRKLLQSHLT

Download         Length: 348 bp

>T51987 NZ_CP010311:c3293148-3292801 [Geoalkalibacter subterraneus]
ATGATCTATGAGGCATTCGATGTCGTGGTCGTGCCTTTTCCTTTTACCGACCGTGCGACCACAAAACGGCGTCCGGCGCT
GATTCTATCTGATGCCGCGATATTTAACCGGCCGGTCGGCCAGGCGGTCATGGCAATGATTACCAGCGCCAGAAATTCCG
ACTGGCCTCTCGATGTTGAAATCGAGGATCTGGATGCAGCCGGCCTGCCGGCTCCCTCCATCGTCAGGATGAAGCTCTTT
ACTCTGGATGAGAAACTTGTCCTGAGAAAAGCCGGGGCACTTGTGGGCGCCGATCGGGGGCGGATTTCTTCAGTGCTGCG
CAAGCTTCTCCAGAGTCATTTAACTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8492.39 Da        Isoelectric Point: 4.2805

>AT51987 WP_040201618.1 NZ_CP010311:c3293368-3293138 [Geoalkalibacter subterraneus]
MQTSTSKLTSKYQATIPEPVRRALQLDAGDAIAFDIENDHITLRKARPVDLAFTQALEGTLTEWESSADEEAYHDL

Download         Length: 231 bp

>AT51987 NZ_CP010311:c3293368-3293138 [Geoalkalibacter subterraneus]
ATGCAGACATCGACCAGCAAGCTAACCTCAAAATACCAGGCGACCATTCCCGAACCCGTCCGTCGTGCTCTGCAACTGGA
CGCCGGTGATGCCATCGCTTTCGACATTGAAAACGATCACATCACCCTGCGCAAGGCCCGCCCCGTTGATCTGGCCTTTA
CTCAGGCGCTGGAAGGCACGCTGACCGAATGGGAATCCTCCGCGGATGAAGAGGCCTATCATGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5FHK1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B5FJW6

References