Detailed information of TA system TA051986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 3251655..3252208
• Replicon: chromosome
• Accession: NZ_CP010311
• Organism: Geoalkalibacter subterraneus strain Red1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GSUB_RS15240
• Protein ID: WP_040201576.1
• Coordinates: 3251655..3251948 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0B5FTX3
• Locus tag: GSUB_RS15245
• Protein ID: WP_040201577.1
• Coordinates: 3251936..3252208 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSUB_RS19430	3246818..3246955	-	138	WP_158414100.1	hypothetical protein	-
GSUB_RS15215	3246979..3247176	-	198	WP_052464990.1	hypothetical protein	-
GSUB_RS15220	3247520..3247786	-	267	WP_144402046.1	hypothetical protein	-
GSUB_RS15225	3248148..3249512	-	1365	WP_040201573.1	putative DNA binding domain-containing protein	-
GSUB_RS15230	3249755..3250861	-	1107	WP_040201574.1	hypothetical protein	-
GSUB_RS15235	3250965..3251192	-	228	WP_040201575.1	antitoxin RHH family protein	-
GSUB_RS15240	3251655..3251948	-	294	WP_040201576.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GSUB_RS15245	3251936..3252208	-	273	WP_040201577.1	CopG family ribbon-helix-helix protein	Antitoxin
GSUB_RS15250	3253022..3253702	-	681	WP_040199265.1	ISAs1 family transposase	-
GSUB_RS18250	3253744..3254811	-	1068	WP_144401929.1	DUF4338 domain-containing protein	-
GSUB_RS15260	3254956..3255636	-	681	WP_040199265.1	ISAs1 family transposase	-
GSUB_RS18255	3255678..3256745	-	1068	WP_144401929.1	DUF4338 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11051.75 Da
• Isoelectric Point: 7.1641

>T51986 WP_040201576.1 NZ_CP010311:c3251948-3251655 [Geoalkalibacter subterraneus]
MPRVVITEGAARGLKRCRRFLMNKSPEAVTHAALAIRERFDLLISQPEIGRPLGDDLDLRELLIEFGDSGYVALYRYDNL
ADVVYVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T51986 NZ_CP010311:c3251948-3251655 [Geoalkalibacter subterraneus]
TTGCCACGAGTAGTTATCACAGAGGGTGCTGCCCGAGGATTAAAGCGGTGTCGGCGCTTCTTGATGAACAAATCACCCGA
AGCTGTGACGCATGCCGCCCTTGCCATACGCGAGCGCTTTGATCTGCTGATCTCACAGCCTGAAATCGGCCGCCCGCTCG
GTGATGACCTCGATTTACGCGAGTTGCTCATCGAATTTGGTGATTCCGGGTATGTTGCGCTCTATCGTTACGATAACCTC
GCAGATGTTGTTTATGTGCTGGCATTCAGGCATCAGAAAGAAGCGGGTTATTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10726.77 Da
• Isoelectric Point: 5.2317

>AT51986 WP_040201577.1 NZ_CP010311:c3252208-3251936 [Geoalkalibacter subterraneus]
MATSIKIDDDLRARIRSLAQRRRRSSHWIMREAIEQYVAREEARESFKQEAYASWSAYQETGRHLTGDEVRDWLGRWGSE
DETELPDCHE

Nucleotide

• Length: 273 bp

>AT51986 NZ_CP010311:c3252208-3251936 [Geoalkalibacter subterraneus]
ATGGCGACCTCTATAAAGATTGATGATGACCTCAGGGCGCGGATACGTTCCCTTGCGCAGCGCCGTCGCCGATCATCTCA
CTGGATTATGCGTGAGGCCATCGAGCAGTATGTGGCGCGGGAAGAGGCGCGCGAGAGCTTTAAGCAGGAGGCTTATGCGT
CCTGGAGTGCTTATCAGGAAACCGGTCGCCACCTGACCGGCGATGAGGTGCGCGATTGGTTGGGCCGTTGGGGATCGGAA
GACGAAACGGAGCTGCCTGATTGCCACGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0B5FTX3