Detailed information of TA system TA051983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1870342..1870967
• Replicon: chromosome
• Accession: NZ_CP010311
• Organism: Geoalkalibacter subterraneus strain Red1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GSUB_RS08670
• Protein ID: WP_040200308.1
• Coordinates: 1870566..1870967 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0B5FR64
• Locus tag: GSUB_RS08665
• Protein ID: WP_040200306.1
• Coordinates: 1870342..1870569 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSUB_RS08645	1866657..1867004	+	348	WP_040200304.1	histidine triad nucleotide-binding protein	-
GSUB_RS08650	1867159..1868463	+	1305	WP_040200305.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
GSUB_RS18040	1868743..1869990	+	1248	WP_052464799.1	CCA tRNA nucleotidyltransferase	-
GSUB_RS08665	1870342..1870569	+	228	WP_040200306.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GSUB_RS08670	1870566..1870967	+	402	WP_040200308.1	type II toxin-antitoxin system VapC family toxin	Toxin
GSUB_RS08675	1871214..1872383	+	1170	WP_040202308.1	Fic family protein	-
GSUB_RS08680	1872664..1872852	+	189	WP_040200310.1	hypothetical protein	-
GSUB_RS08685	1873269..1873541	+	273	WP_040200311.1	hypothetical protein	-
GSUB_RS08690	1873538..1873837	+	300	WP_040200313.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GSUB_RS18595	1874071..1874394	-	324	WP_084211895.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GSUB_RS08695	1874400..1874666	-	267	WP_040200315.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14851.19 Da
• Isoelectric Point: 4.9000

>T51983 WP_040200308.1 NZ_CP010311:1870566-1870967 [Geoalkalibacter subterraneus]
MMLMLDTNICIYIIKQRPPEVLKRFLEYQVGDIAISTITLAELRYGVAKSHYPDKNTQALDDFILPLEILPFDEEATRSY
GEIRASLEKAGTPIGSMDLLIAAHAVSQGVTLVTNNSREFERVPGLKAVNWAV

Nucleotide

• Length: 402 bp

>T51983 NZ_CP010311:1870566-1870967 [Geoalkalibacter subterraneus]
CTGATGTTGATGCTGGATACCAATATTTGCATTTACATCATCAAGCAGAGGCCGCCGGAAGTGCTCAAGCGATTCCTTGA
GTATCAGGTCGGTGACATTGCCATCTCTACGATCACGCTGGCTGAATTGCGCTATGGCGTTGCTAAAAGTCACTATCCAG
ACAAGAATACCCAAGCTCTCGATGATTTCATTCTTCCCTTGGAGATCCTTCCTTTCGATGAAGAAGCGACACGATCCTAT
GGCGAAATCCGAGCCTCGCTGGAAAAAGCGGGGACGCCGATCGGATCCATGGACCTGCTGATTGCCGCCCATGCCGTTTC
GCAGGGCGTGACTTTAGTGACAAACAACTCCAGGGAATTCGAGCGGGTTCCTGGACTGAAAGCTGTCAACTGGGCCGTTT
AA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9014.39 Da
• Isoelectric Point: 10.4281

>AT51983 WP_040200306.1 NZ_CP010311:1870342-1870569 [Geoalkalibacter subterraneus]
MKKAKIFQNGQSQAVRLPKEFRFNDKEVYIKKTGHVVHLIPKTDSWDILFDSLKKFSKDFMAERVQPEQDRRENF

Nucleotide

• Length: 228 bp

>AT51983 NZ_CP010311:1870342-1870569 [Geoalkalibacter subterraneus]
ATGAAAAAAGCAAAAATTTTCCAGAATGGCCAAAGCCAGGCGGTTCGGTTACCTAAGGAGTTTCGCTTTAACGACAAAGA
GGTTTATATAAAAAAAACCGGACATGTCGTCCACCTCATTCCGAAAACTGATTCATGGGATATCCTCTTTGACAGCCTGA
AGAAGTTTTCCAAGGATTTTATGGCGGAGCGGGTCCAGCCTGAGCAAGACAGGCGGGAGAACTTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0B5FR64