Detailed information of TA system TA051981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 1733443..1733945
• Replicon: chromosome
• Accession: NZ_CP010311
• Organism: Geoalkalibacter subterraneus strain Red1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A0B5FPC4
• Locus tag: GSUB_RS07970
• Protein ID: WP_040200130.1
• Coordinates: 1733691..1733945 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0B5FGR3
• Locus tag: GSUB_RS07965
• Protein ID: WP_040200129.1
• Coordinates: 1733443..1733694 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSUB_RS07945	1728621..1729049	+	429	WP_052464750.1	GxxExxY protein	-
GSUB_RS07950	1729046..1730323	+	1278	WP_040200127.1	glycosyltransferase	-
GSUB_RS07955	1730527..1731609	+	1083	WP_040202273.1	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-
GSUB_RS07960	1731731..1732978	+	1248	WP_040200128.1	glycosyltransferase, exosortase A system-associated	-
GSUB_RS07965	1733443..1733694	+	252	WP_040200129.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
GSUB_RS07970	1733691..1733945	+	255	WP_040200130.1	Txe/YoeB family addiction module toxin	Toxin
GSUB_RS07980	1734124..1734312	+	189	WP_040200133.1	hypothetical protein	-
GSUB_RS07985	1734300..1734596	+	297	WP_040200134.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GSUB_RS07990	1734677..1735075	+	399	WP_144401982.1	nucleotidyltransferase domain-containing protein	-
GSUB_RS07995	1735063..1735491	+	429	WP_144401983.1	DUF86 domain-containing protein	-
GSUB_RS08000	1735805..1736056	+	252	WP_040200136.1	addiction module protein	-
GSUB_RS08005	1736304..1736549	+	246	WP_040200137.1	hypothetical protein	-
GSUB_RS08010	1736542..1736772	+	231	WP_040200138.1	hypothetical protein	-
GSUB_RS19390	1736918..1737088	+	171	WP_158414062.1	hypothetical protein	-
GSUB_RS08015	1737792..1738082	+	291	WP_040202276.1	nucleotidyltransferase	-
GSUB_RS08020	1738075..1738419	+	345	WP_040200139.1	DUF86 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10029.40 Da
• Isoelectric Point: 9.8552

>T51981 WP_040200130.1 NZ_CP010311:1733691-1733945 [Geoalkalibacter subterraneus]
VKLIFSENAWDDYQYWIKTDKKILKRVNALIQDIQRSPFSGTGKPEPLKHGLSGYWSRRINDEHRIVYKATDDSIFIAQV
RYHY

Nucleotide

• Length: 255 bp

>T51981 NZ_CP010311:1733691-1733945 [Geoalkalibacter subterraneus]
GTGAAGCTCATATTTTCCGAAAATGCTTGGGATGACTACCAGTATTGGATAAAAACCGATAAGAAGATCCTCAAGCGGGT
GAACGCATTGATTCAGGATATACAGCGTTCACCTTTTTCTGGTACCGGGAAGCCCGAACCATTGAAACATGGTCTTTCCG
GCTATTGGTCCAGGCGAATTAACGATGAACACAGAATCGTTTATAAAGCTACGGATGACTCCATTTTCATTGCTCAGGTC
CGCTACCACTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9446.64 Da
• Isoelectric Point: 4.6656

>AT51981 WP_040200129.1 NZ_CP010311:1733443-1733694 [Geoalkalibacter subterraneus]
MEAISYTNARSNLAKTMEKVCEDHDPVIITRRNESSVVMMSLEDYQALEETAYLLRSPKNARRLLESIAQLESGDGAERE
LTR

Nucleotide

• Length: 252 bp

>AT51981 NZ_CP010311:1733443-1733694 [Geoalkalibacter subterraneus]
ATGGAAGCTATTTCGTACACCAACGCAAGAAGCAACTTAGCAAAAACAATGGAAAAAGTCTGCGAAGACCATGATCCTGT
CATTATCACACGCCGGAACGAAAGCTCGGTTGTTATGATGTCTCTTGAAGATTACCAAGCTCTTGAAGAGACTGCGTATT
TGCTGAGAAGCCCTAAAAATGCTCGACGTCTTTTGGAGTCGATTGCTCAGTTAGAGTCTGGTGACGGTGCTGAGCGGGAG
CTTACTCGGTGA

Structures

Toxin

• AlphaFold DB: A0A0B5FPC4

Antitoxin

• AlphaFold DB: A0A0B5FGR3