Detailed information of TA system TA051978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3847271..3848649
• Replicon: chromosome
• Accession: NZ_CP010310
• Organism: Pandoraea pulmonicola strain DSM 16583

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: RO07_RS16395
• Protein ID: WP_084072861.1
• Coordinates: 3847933..3848649 (+)
• Length: 239 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RO07_RS16390
• Protein ID: WP_115089098.1
• Coordinates: 3847271..3847831 (+)
• Length: 187 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RO07_RS16380	3842900..3845524	-	2625	WP_039412441.1	alanine--tRNA ligase	-
RO07_RS16385	3845775..3846998	+	1224	WP_039412444.1	CoA transferase	-
RO07_RS16390	3847271..3847831	+	561	WP_115089098.1	helix-turn-helix transcriptional regulator	Antitoxin
RO07_RS16395	3847933..3848649	+	717	WP_084072861.1	HD domain-containing protein	Toxin
RO07_RS16400	3848555..3849127	+	573	WP_039412447.1	cysteine hydrolase	-
RO07_RS26075	3849679..3850587	+	909	WP_157118214.1	hypothetical protein	-
RO07_RS16410	3850617..3852101	-	1485	WP_147284633.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-165)

Antitoxin

• Cro/C1-type helix-turn-helix domain (26-64)

Sequences

Toxin

Protein

• Length: 239 a.a.
• Molecular weight: 26599.91 Da
• Isoelectric Point: 6.5842

>T51978 WP_084072861.1 NZ_CP010310:3847933-3848649 [Pandoraea pulmonicola]
MARESIEGRLNFLRTCERLKDVLRSGHTSSGRPESTAEHSWRLSLMAMVFMDRLGDVDRAKMLELCVVHDLGEALNGDVP
APEQQGGVDKNDAERQDLLTICESLDAPMRDRIVALWDEYARGATPEARAVKALDKLETMLQHTQGRNPPDFDYAFNLAY
GRQYTDATPFLRAVRERIDEATRERGAAARLAPHEVGSDLTIARGKRDEHCTDRPGLHSGHHSPIGEAGAMRRARRCA

Nucleotide

• Length: 717 bp

>T51978 NZ_CP010310:3847933-3848649 [Pandoraea pulmonicola]
ATGGCGCGCGAGTCGATTGAAGGACGACTGAATTTTCTGCGGACGTGCGAGCGGTTGAAGGATGTGCTCAGAAGCGGCCA
TACGTCATCGGGACGGCCGGAGAGCACGGCGGAGCACAGCTGGCGGCTGAGTCTCATGGCGATGGTGTTCATGGATCGAC
TGGGCGACGTGGACCGCGCGAAGATGCTGGAGTTGTGTGTCGTCCACGATCTTGGGGAAGCGTTGAACGGCGATGTGCCT
GCGCCCGAACAACAAGGGGGTGTGGACAAGAACGATGCCGAACGGCAGGATCTGCTGACGATATGCGAGTCGCTGGATGC
ACCAATGCGCGACCGGATCGTGGCATTGTGGGACGAGTATGCGCGGGGAGCAACACCGGAGGCGCGCGCCGTAAAGGCGC
TCGACAAACTGGAGACGATGCTGCAGCACACGCAAGGCCGCAATCCGCCGGACTTCGACTACGCGTTCAATCTCGCCTAT
GGACGCCAATACACGGACGCGACGCCCTTTCTTCGTGCCGTGCGCGAACGGATCGACGAGGCGACGCGCGAACGCGGTGC
GGCGGCGCGACTCGCTCCGCATGAGGTAGGAAGCGACTTGACCATCGCAAGGGGAAAACGAGATGAACACTGCACTGATC
GGCCTGGACTACATTCTGGACATCATTCACCCATCGGGGAAGCCGGCGCGATGCGCCGCGCACGCCGCTGCGCGTGA

Antitoxin

Protein

• Length: 187 a.a.
• Molecular weight: 20173.89 Da
• Isoelectric Point: 8.3310

>AT51978 WP_115089098.1 NZ_CP010310:3847271-3847831 [Pandoraea pulmonicola]
MEHGMDRPAMASAGSALRRWRALRRIKQAHAAEWFGVAQSTLSRWEAGTLPITGDALVRLESLLSARLDSAADSALQRLV
THDTRAVHLVCDVTHRLLACSAARAAEFSSPLSTLMGASLWPFATQAIVSREASLRDAGWHDGQAPSLEFDTGSNDSVAV
PIRASRCRWTRLTLSDGTVARLVETL

Nucleotide

• Length: 561 bp

>AT51978 NZ_CP010310:3847271-3847831 [Pandoraea pulmonicola]
ATGGAACATGGCATGGACAGGCCTGCGATGGCGTCGGCGGGCAGTGCGCTGCGACGATGGCGCGCGCTGCGACGCATCAA
GCAGGCGCACGCGGCCGAGTGGTTCGGCGTTGCGCAATCGACGTTGTCGCGCTGGGAGGCCGGCACGCTGCCGATCACGG
GTGACGCGCTCGTGCGTCTCGAATCGCTGCTTTCGGCGCGTCTCGACTCGGCGGCCGACAGCGCGTTGCAGCGCCTGGTG
ACGCACGACACGCGTGCGGTGCATCTCGTGTGCGACGTCACGCATCGCTTGCTCGCGTGCTCGGCGGCTCGTGCGGCGGA
GTTTTCATCGCCATTGTCGACGTTGATGGGTGCGTCGCTGTGGCCTTTCGCGACGCAGGCGATCGTCTCGCGGGAGGCGT
CGCTGCGCGACGCGGGGTGGCATGACGGGCAAGCGCCGTCGCTGGAATTCGATACCGGCAGCAACGATTCGGTGGCGGTG
CCGATCCGGGCAAGTCGTTGCCGATGGACGCGTCTCACGCTCTCGGACGGCACCGTTGCGCGTCTGGTCGAGACACTGTG
A