Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1054584..1055149 Replicon chromosome
Accession NZ_CP010310
Organism Pandoraea pulmonicola strain DSM 16583

Toxin (Protein)


Gene name vapC Uniprot ID A0A378Z2G6
Locus tag RO07_RS04745 Protein ID WP_039408501.1
Coordinates 1054778..1055149 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5E4UNK5
Locus tag RO07_RS04740 Protein ID WP_039408500.1
Coordinates 1054584..1054781 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RO07_RS04710 1050010..1050480 + 471 WP_052267018.1 DUF4212 domain-containing protein -
RO07_RS04715 1050477..1052495 + 2019 WP_039408496.1 cation acetate symporter -
RO07_RS04725 1052771..1053190 - 420 WP_039408497.1 type II toxin-antitoxin system HicB family antitoxin -
RO07_RS04730 1053283..1053468 - 186 WP_039408498.1 type II toxin-antitoxin system HicA family toxin -
RO07_RS04735 1053717..1053962 - 246 WP_039408499.1 hypothetical protein -
RO07_RS04740 1054584..1054781 + 198 WP_039408500.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RO07_RS04745 1054778..1055149 + 372 WP_039408501.1 type II toxin-antitoxin system VapC family toxin Toxin
RO07_RS04750 1055789..1056463 + 675 WP_147284557.1 response regulator transcription factor -
RO07_RS04755 1056447..1059848 + 3402 WP_147284556.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13205.36 Da        Isoelectric Point: 6.4779

>T51977 WP_039408501.1 NZ_CP010310:1054778-1055149 [Pandoraea pulmonicola]
MILVDTSVWIDHLRSGDAALVQLLETARVLAHPYVIGELALGSLKNRDIVISTLGDLPRVTVATDDEVLRFVGEQALFGL
GIGCVDVHLLAATRLTPGAALWTRDKRLAATAERLSLAAKISH

Download         Length: 372 bp

>T51977 NZ_CP010310:1054778-1055149 [Pandoraea pulmonicola]
ATGATTCTGGTCGACACGTCAGTTTGGATTGACCATTTACGATCAGGTGATGCTGCACTCGTCCAGTTGCTTGAGACTGC
ACGAGTGTTGGCGCATCCGTACGTCATCGGTGAGCTTGCGCTCGGTAGCCTGAAGAATCGCGACATCGTAATTTCCACGT
TGGGCGATCTACCTCGTGTAACGGTTGCCACTGATGACGAGGTGTTGCGGTTCGTCGGTGAGCAAGCTCTCTTCGGCCTG
GGGATTGGCTGCGTTGACGTGCATCTACTTGCCGCAACTCGCCTGACTCCGGGGGCCGCTTTGTGGACTCGAGATAAGCG
TCTTGCTGCGACGGCCGAGCGGCTTTCGTTAGCCGCGAAAATCTCGCACTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7147.18 Da        Isoelectric Point: 6.3084

>AT51977 WP_039408500.1 NZ_CP010310:1054584-1054781 [Pandoraea pulmonicola]
MRTTLALDDELLAKAQAFTGLQEKSALIREALKALIERESARRLARLGGTEADLGDIPRRQTEPA

Download         Length: 198 bp

>AT51977 NZ_CP010310:1054584-1054781 [Pandoraea pulmonicola]
ATGCGAACGACATTGGCCCTTGATGATGAGCTTTTGGCGAAGGCTCAAGCCTTCACCGGTTTGCAGGAAAAATCAGCGCT
GATCCGCGAGGCACTCAAGGCGTTGATCGAGCGCGAAAGCGCCCGCCGCTTGGCTCGTTTGGGAGGGACCGAGGCTGACC
TTGGTGACATTCCTCGACGCCAAACGGAGCCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378Z2G6

Antitoxin

Source ID Structure
AlphaFold DB A0A5E4UNK5

References