Detailed information of TA system TA051976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 1052771..1053468
• Replicon: chromosome
• Accession: NZ_CP010310
• Organism: Pandoraea pulmonicola strain DSM 16583

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: RO07_RS04730
• Protein ID: WP_039408498.1
• Coordinates: 1053283..1053468 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A378Z4F8
• Locus tag: RO07_RS04725
• Protein ID: WP_039408497.1
• Coordinates: 1052771..1053190 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RO07_RS04705	1047993..1049975	+	1983	WP_039408494.1	acetate--CoA ligase	-
RO07_RS04710	1050010..1050480	+	471	WP_052267018.1	DUF4212 domain-containing protein	-
RO07_RS04715	1050477..1052495	+	2019	WP_039408496.1	cation acetate symporter	-
RO07_RS04725	1052771..1053190	-	420	WP_039408497.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RO07_RS04730	1053283..1053468	-	186	WP_039408498.1	type II toxin-antitoxin system HicA family toxin	Toxin
RO07_RS04735	1053717..1053962	-	246	WP_039408499.1	hypothetical protein	-
RO07_RS04740	1054584..1054781	+	198	WP_039408500.1	type II toxin-antitoxin system VapB family antitoxin	-
RO07_RS04745	1054778..1055149	+	372	WP_039408501.1	type II toxin-antitoxin system VapC family toxin	-
RO07_RS04750	1055789..1056463	+	675	WP_147284557.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6974.02 Da
• Isoelectric Point: 10.8173

>T51976 WP_039408498.1 NZ_CP010310:c1053468-1053283 [Pandoraea pulmonicola]
MKYSEFRKWLKQQGATFERHRSGSSHFRVTLNGKATIFPDHGAKEIGTGLVEAIKKQLDLK

Nucleotide

• Length: 186 bp

>T51976 NZ_CP010310:c1053468-1053283 [Pandoraea pulmonicola]
ATGAAGTACAGCGAATTTCGAAAGTGGTTGAAGCAGCAAGGCGCAACGTTTGAAAGGCATCGCTCCGGTTCAAGCCACTT
CCGCGTGACCTTGAATGGTAAAGCGACAATTTTCCCGGACCACGGTGCCAAAGAGATCGGTACTGGTCTCGTTGAGGCGA
TAAAGAAGCAGCTCGATCTTAAGTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15527.18 Da
• Isoelectric Point: 7.9945

>AT51976 WP_039408497.1 NZ_CP010310:c1053190-1052771 [Pandoraea pulmonicola]
MLSYPIEMRPDTNGTLLVTFPDVPEAITVGENKEDALVQALDALEAALEIYFAEKREIPRPSRPKKGQRCITLPILASMK
VLLANEMLAQNVRKAELARRMHVNQVQVDRLLKLGYASKLDAVESAFEALGKRLEVRAV

Nucleotide

• Length: 420 bp

>AT51976 NZ_CP010310:c1053190-1052771 [Pandoraea pulmonicola]
ATGTTGAGCTATCCGATTGAGATGCGACCGGACACAAACGGAACGCTGTTGGTCACGTTCCCGGATGTCCCCGAGGCAAT
CACCGTTGGTGAGAACAAAGAAGATGCACTAGTGCAGGCGCTGGATGCGCTGGAAGCGGCTCTGGAAATTTATTTTGCGG
AAAAGCGCGAGATCCCGCGCCCGTCGCGGCCAAAGAAAGGGCAGCGGTGTATCACGCTTCCGATTCTGGCCTCGATGAAA
GTGCTTTTGGCCAACGAAATGTTGGCGCAAAACGTCCGCAAAGCCGAGCTCGCAAGACGTATGCACGTCAACCAGGTTCA
GGTCGATCGGCTTTTGAAGCTCGGCTATGCATCGAAGCTGGATGCCGTTGAGAGCGCGTTCGAAGCCCTCGGTAAGCGCC
TTGAAGTGCGGGCCGTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A378Z4F8