51908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2188031..2188560 Replicon chromosome
Accession NZ_CP010299
Organism Staphylococcus aureus strain ATCC BAA1680

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag RM27_RS10305 Protein ID WP_000621175.1
Coordinates 2188031..2188393 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag RM27_RS10310 Protein ID WP_000948331.1
Coordinates 2188390..2188560 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RM27_RS10285 2185009..2185779 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
RM27_RS10290 2185754..2186233 - 480 WP_001190829.1 anti-sigma B factor RsbW -
RM27_RS10295 2186235..2186561 - 327 WP_001052491.1 anti-sigma factor antagonist -
RM27_RS10300 2186680..2187681 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
RM27_RS10305 2188031..2188393 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RM27_RS10310 2188390..2188560 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
RM27_RS10315 2188645..2189793 - 1149 WP_001281145.1 alanine racemase -
RM27_RS10320 2189859..2190218 - 360 WP_000581200.1 holo-ACP synthase -
RM27_RS10325 2190222..2190713 - 492 WP_001205910.1 PH domain-containing protein -
RM27_RS10330 2190700..2192283 - 1584 WP_001294626.1 PH domain-containing protein -
RM27_RS10335 2192276..2192755 - 480 WP_001287088.1 hypothetical protein -
RM27_RS10340 2192963..2193523 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T51908 WP_000621175.1 NZ_CP010299:c2188393-2188031 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T51908 NZ_CP010299:c2188393-2188031 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT51908 WP_000948331.1 NZ_CP010299:c2188560-2188390 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT51908 NZ_CP010299:c2188560-2188390 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References