51884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 869362..869839 Replicon chromosome
Accession NZ_CP010298
Organism Staphylococcus aureus strain ATCC BAA1680

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RM31_RS03935 Protein ID WP_000052078.1
Coordinates 869362..869550 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RM31_RS03940 Protein ID WP_001059690.1
Coordinates 869579..869839 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RM31_RS03905 865403..865873 + 471 WP_000824472.1 hypothetical protein -
RM31_RS03910 866214..866900 + 687 WP_001548082.1 thermonuclease family protein -
RM31_RS03915 867257..867457 + 201 WP_001059082.1 cold-shock protein -
RM31_RS03920 867953..868171 - 219 WP_000005886.1 hypothetical protein -
RM31_RS03925 868233..868517 - 285 WP_001004395.1 hypothetical protein -
RM31_RS03930 868605..869174 - 570 WP_001106654.1 hypothetical protein -
RM31_RS03935 869362..869550 - 189 WP_000052078.1 hypothetical protein Toxin
RM31_RS03940 869579..869839 - 261 WP_001059690.1 hypothetical protein Antitoxin
RM31_RS03945 870180..870383 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RM31_RS03950 870380..870616 - 237 WP_000368687.1 hypothetical protein -
RM31_RS03955 870841..871422 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
RM31_RS03960 871495..872112 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RM31_RS03965 872267..872761 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RM31_RS03970 873160..873582 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RM31_RS03975 873730..874446 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / selk / selq 851510..895128 43618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T51884 WP_000052078.1 NZ_CP010298:c869550-869362 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T51884 NZ_CP010298:c869550-869362 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT51884 WP_001059690.1 NZ_CP010298:c869839-869579 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT51884 NZ_CP010298:c869839-869579 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References