Detailed information of TA system TA051834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 1403445..1404423
• Replicon: chromosome
• Accession: NZ_CP010272
• Organism: Bacillus cereus strain FORC_010

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: FORC10_RS06830
• Protein ID: WP_000624974.1
• Coordinates: 1403686..1404423 (-)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W8YZL5
• Locus tag: FORC10_RS06825
• Protein ID: WP_000237818.1
• Coordinates: 1403445..1403573 (-)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC10_RS06800 (FORC10_1324)	1399423..1400025	-	603	WP_000517268.1	hypothetical protein	-
FORC10_RS06805 (FORC10_1325)	1400051..1400860	-	810	WP_070179292.1	papain-like cysteine protease family protein	-
FORC10_RS06810 (FORC10_1326)	1401106..1402575	-	1470	WP_000287547.1	beta-Ala-His dipeptidase	-
FORC10_RS06815 (FORC10_1327)	1402787..1403176	+	390	WP_048558853.1	YxeA family protein	-
FORC10_RS06820 (FORC10_1328)	1403196..1403372	-	177	WP_000852629.1	stage II sporulation protein SB	-
FORC10_RS06825	1403445..1403573	-	129	WP_000237818.1	hypothetical protein	Antitoxin
FORC10_RS06830 (FORC10_1329)	1403686..1404423	-	738	WP_000624974.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
FORC10_RS06835 (FORC10_1330)	1404662..1405399	-	738	WP_048558852.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
FORC10_RS06840 (FORC10_1331)	1405566..1406048	-	483	WP_000191887.1	MarR family winged helix-turn-helix transcriptional regulator	-
FORC10_RS06845 (FORC10_1332)	1406165..1407841	+	1677	WP_048558851.1	alpha-keto acid decarboxylase family protein	-
FORC10_RS06850 (FORC10_1333)	1407999..1408781	-	783	WP_016512842.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28375.07 Da
• Isoelectric Point: 8.3170

>T51834 WP_000624974.1 NZ_CP010272:c1404423-1403686 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTHWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFTDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIIIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T51834 NZ_CP010272:c1404423-1403686 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACTGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCACTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACACCTAATATTTCAGAAATATGGGGTGCGAAATTTACCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAACCCATCAGTATTCGGTACGATGG
AATGGCATACAGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAATTAAATACAAACTTTCGGGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTATTATTGATGGAAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5011.40 Da
• Isoelectric Point: 3.9150

>AT51834 WP_000237818.1 NZ_CP010272:c1403573-1403445 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT51834 NZ_CP010272:c1403573-1403445 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACCGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Antitoxin

• AlphaFold DB: W8YZL5