Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 215158..216593 Replicon chromosome
Accession NZ_CP010267
Organism Mycoplasma mycoides subsp. mycoides strain izsam_mm5713

Toxin (Protein)


Gene name abiEii Uniprot ID A0A7U5HSR7
Locus tag mycmycITA_RS00965 Protein ID WP_039275567.1
Coordinates 215158..215997 (-) Length 280 a.a.

Antitoxin (Protein)


Gene name abiEi Uniprot ID A0A7U5HSJ1
Locus tag mycmycITA_RS00970 Protein ID WP_015545367.1
Coordinates 215997..216593 (-) Length 199 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
mycmycITA_RS06730 211759..211923 + 165 WP_015545676.1 hypothetical protein -
mycmycITA_RS00950 212036..213637 + 1602 WP_162465392.1 IS1634 family transposase -
mycmycITA_RS06790 213703..215117 + 1415 WP_162465382.1 IS3 family transposase -
mycmycITA_RS00965 215158..215997 - 840 WP_039275567.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
mycmycITA_RS00970 215997..216593 - 597 WP_015545367.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
mycmycITA_RS00975 216803..218107 - 1305 WP_011166379.1 DUF285 domain-containing protein -
mycmycITA_RS00980 218213..220903 - 2691 WP_011166380.1 alanine--tRNA ligase -
mycmycITA_RS00985 220975..221469 - 495 WP_011166381.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-53)


Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 33013.96 Da        Isoelectric Point: 9.6440

>T51832 WP_039275567.1 NZ_CP010267:c215997-215158 [Mycoplasma mycoides subsp. mycoides]
MNLQKLKSICKRLSSETKTNYNIILKHYFMISILEKIVKSKNKQNFVIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKE
NILRTISDVLRYDFTDFIKYEIKEITEIKKRDKYNGFRVKILCKLEKLEEIVKIDLAIGDVVTPSEIKCNFRNIFSNSSF
EIQAYNLETILAEKIFIINNLNIQSTRIKDLYDIFLIYSFKEFEIDYNILKCACLNTFKKRNTVFNIDLVLSLLNEINQL
DIFELLNNYRQKYFYAQKIEFKILIKSVIKFLEKLKNI

Download         Length: 840 bp

>T51832 NZ_CP010267:c215997-215158 [Mycoplasma mycoides subsp. mycoides]
ATGAACTTACAGAAATTAAAATCAATTTGTAAAAGGTTATCAAGTGAAACAAAAACAAATTATAATATCATCTTAAAACA
TTACTTTATGATATCCATATTAGAAAAAATTGTTAAAAGTAAAAATAAACAAAACTTTGTAATTAAAGGTGGGTTCTTAC
TTTCTAATATGATGAGTTTAAACGAAAGAACCACTCAAGATATAGATTGCTTAATAAAAGGTATCAATTTTGTTAAAGAG
AATATTCTAAGAACTATTTCTGATGTATTAAGATATGATTTTACTGACTTTATAAAATATGAAATAAAAGAAATAACAGA
AATAAAAAAGAGAGACAAATATAATGGATTTAGAGTCAAAATATTATGCAAATTAGAAAAGTTGGAAGAAATAGTAAAAA
TAGATTTAGCAATTGGTGATGTTGTAACACCGTCTGAGATTAAATGCAATTTTAGAAATATCTTTTCAAATAGTAGCTTT
GAAATACAAGCATATAATCTAGAAACAATATTAGCTGAAAAAATATTTATAATTAATAATTTAAATATACAATCAACTAG
AATAAAAGATCTTTATGATATTTTTTTAATATATAGCTTTAAAGAGTTTGAGATTGATTATAATATTCTAAAATGTGCTT
GTTTAAATACTTTTAAAAAAAGAAATACTGTTTTTAATATAGATTTAGTACTTAGTTTATTAAATGAAATTAACCAATTA
GATATTTTTGAATTACTTTGAAATAATTACAGGCAAAAATACTTTTACGCCCAAAAAATAGAATTTAAAATACTGATAAA
ATCTGTAATTAAGTTTTTAGAAAAGTTAAAAAATATTTAA

Antitoxin


Download         Length: 199 a.a.        Molecular weight: 23637.30 Da        Isoelectric Point: 9.3217

>AT51832 WP_015545367.1 NZ_CP010267:c216593-215997 [Mycoplasma mycoides subsp. mycoides]
MNYKEQLIKEAKKRAGIITRKEIMNLKIPSIYITRMIRSNELEKVDIGIYALTSENWYYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKIRAYDIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKRDKKLHEYAKKMNIGKKVYEVFQVLV

Download         Length: 597 bp

>AT51832 NZ_CP010267:c216593-215997 [Mycoplasma mycoides subsp. mycoides]
ATGAATTATAAAGAACAGCTGATAAAAGAAGCTAAAAAAAGAGCCGGTATTATTACAAGAAAAGAAATTATGAATTTAAA
AATTCCATCAATTTATATTACAAGAATGATTAGAAGTAATGAATTAGAAAAAGTCGATATTGGTATTTATGCTCTAACTT
CTGAAAATTGGTACTATGATCCTGATTATAATTTTAGTATCAGACATAAAACACCTATTTTTTCTTATACTTATGCACTT
ACATTTTTTGATTTTACAGATGTTATTCCAATGTTTCGTGATGTAACTGTTTATCATGGATATAATGCTCATAATTTAGA
CCCACAAACTAGAGTACACTATGTTTCAAAAGATATATATGAACTTGGAGTTGTAGAAGTAAAAACAAATTGTGGTAATA
AAATTAGAGCTTATGATATTGAAAGAACAATTTGTGATTTTATTAAGCATAGAGATAAAATCGAAGCTGAACTATTTGCA
AAAACTATGTATAAATATTCTGAATATGAAAAAAGAGATTGAAAAAAACTTCATGAATATGCTAAAAAAATGAACATTGG
TAAGAAAGTTTATGAAGTTTTTCAAGTATTAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5HSR7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5HSJ1

References