Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3627990..3628516 | Replicon | chromosome |
| Accession | NZ_CP010240 | ||
| Organism | Escherichia coli strain C7 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | RG29_RS19215 | Protein ID | WP_000323025.1 |
| Coordinates | 3627990..3628277 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | RG29_RS19220 | Protein ID | WP_000534858.1 |
| Coordinates | 3628277..3628516 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG29_RS19175 | 3623025..3623240 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| RG29_RS30655 | 3623460..3623630 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| RG29_RS19180 | 3623994..3624209 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| RG29_RS19185 | 3624509..3624721 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| RG29_RS30050 | 3624776..3624865 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| RG29_RS19190 | 3625133..3625885 | - | 753 | WP_001047135.1 | antitermination protein | - |
| RG29_RS19195 | 3625899..3626948 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| RG29_RS19200 | 3626950..3627228 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| RG29_RS19205 | 3627295..3627546 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| RG29_RS19210 | 3627763..3627918 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| RG29_RS19215 | 3627990..3628277 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| RG29_RS19220 | 3628277..3628516 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| RG29_RS19225 | 3628541..3628846 | + | 306 | WP_071527819.1 | hypothetical protein | - |
| RG29_RS19235 | 3629049..3629381 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| RG29_RS19240 | 3629818..3631158 | - | 1341 | WP_000589015.1 | ISNCY family transposase | - |
| RG29_RS19245 | 3631192..3631611 | - | 420 | WP_001151196.1 | DUF977 family protein | - |
| RG29_RS19250 | 3631652..3632617 | - | 966 | WP_000054504.1 | hypothetical protein | - |
| RG29_RS19255 | 3632598..3633119 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| RG29_RS19260 | 3633103..3633330 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3590700..3638492 | 47792 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T51739 WP_000323025.1 NZ_CP010240:c3628277-3627990 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T51739 NZ_CP010240:c3628277-3627990 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT51739 WP_000534858.1 NZ_CP010240:c3628516-3628277 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT51739 NZ_CP010240:c3628516-3628277 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|