Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2372154..2372986 Replicon chromosome
Accession NZ_CP010240
Organism Escherichia coli strain C7

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag RG29_RS12330 Protein ID WP_001094452.1
Coordinates 2372612..2372986 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TJC4
Locus tag RG29_RS12325 Protein ID WP_001285579.1
Coordinates 2372154..2372522 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG29_RS12305 2369904..2370721 + 818 Protein_2191 DUF945 domain-containing protein -
RG29_RS12310 2370813..2371298 + 486 WP_000206663.1 antirestriction protein -
RG29_RS12315 2371314..2371790 + 477 WP_001186706.1 RadC family protein -
RG29_RS12320 2371853..2372074 + 222 WP_000692345.1 DUF987 domain-containing protein -
RG29_RS12325 2372154..2372522 + 369 WP_001285579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG29_RS12330 2372612..2372986 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
RG29_RS12335 2372983..2373474 + 492 WP_000976868.1 hypothetical protein -
RG29_RS12340 2373486..2373683 + 198 WP_000772035.1 DUF957 domain-containing protein -
RG29_RS12345 2373780..2374622 + 843 WP_001290259.1 DUF4942 domain-containing protein -
RG29_RS12350 2374903..2375439 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
RG29_RS12355 2375441..2376619 - 1179 WP_000094974.1 type II secretion system protein GspL -
RG29_RS12360 2376616..2377593 - 978 WP_000633238.1 type II secretion system minor pseudopilin GspK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T51724 WP_001094452.1 NZ_CP010240:2372612-2372986 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T51724 NZ_CP010240:2372612-2372986 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCTCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCACCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13580.39 Da        Isoelectric Point: 7.3223

>AT51724 WP_001285579.1 NZ_CP010240:2372154-2372522 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT51724 NZ_CP010240:2372154-2372522 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAAAGGGCTGACCTGCAAAGCCGACACCCTCGGTAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8DWX2

References