Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 78052..78587 Replicon plasmid A
Accession NZ_CP010239
Organism Escherichia coli strain S50

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag RG72_RS25890 Protein ID WP_001270415.1
Coordinates 78052..78339 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag RG72_RS25895 Protein ID WP_001132890.1
Coordinates 78336..78587 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG72_RS25860 74174..75712 - 1539 WP_053886755.1 IS66 family transposase -
RG72_RS25865 75762..76109 - 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
RG72_RS28180 76106..76486 - 381 WP_024239145.1 IS66 family insertion sequence hypothetical protein -
RG72_RS25875 76530..76766 + 237 Protein_95 transposase domain-containing protein -
RG72_RS25885 77217..77519 - 303 WP_032232226.1 hypothetical protein -
RG72_RS25890 78052..78339 - 288 WP_001270415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG72_RS25895 78336..78587 - 252 WP_001132890.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RG72_RS25900 78759..78971 - 213 WP_000402944.1 hypothetical protein -
RG72_RS27260 79249..79856 - 608 Protein_100 transposase -
RG72_RS27265 79915..81128 - 1214 Protein_101 IS3 family transposase -
RG72_RS25940 81217..82092 - 876 WP_024239053.1 hypothetical protein -
RG72_RS27915 82365..82797 - 433 Protein_103 T3SS effector protein NleH -
RG72_RS25955 82874..83188 - 315 WP_001303878.1 PerC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / blaDHA-1 / qnrB4 hlyC / hlyA / hlyB / hlyD / senB / pet 1..184614 184614
- inside IScluster/Tn - - 59281..81128 21847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11163.21 Da        Isoelectric Point: 10.4350

>T51710 WP_001270415.1 NZ_CP010239:c78339-78052 [Escherichia coli]
MRYQVKFREDALKEWQKLDKAIQQHFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVCQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T51710 NZ_CP010239:c78339-78052 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACATTTTGC
GAAAAAGCTCAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTAGTCTGTCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGCGAAAGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.53 Da        Isoelectric Point: 4.2108

>AT51710 WP_001132890.1 NZ_CP010239:c78587-78336 [Escherichia coli]
MPNIILCDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp

>AT51710 NZ_CP010239:c78587-78336 [Escherichia coli]
ATGCCTAACATTATTCTCTGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCTACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTATACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTAGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References