Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2516378..2516973 Replicon chromosome
Accession NZ_CP010238
Organism Escherichia coli strain S50

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag RG72_RS13205 Protein ID WP_000239579.1
Coordinates 2516623..2516973 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag RG72_RS13200 Protein ID WP_001223207.1
Coordinates 2516378..2516629 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG72_RS13190 2512042..2515821 + 3780 WP_000060927.1 autotransporter assembly complex protein TamB -
RG72_RS13195 2515824..2516165 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
RG72_RS13200 2516378..2516629 + 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
RG72_RS13205 2516623..2516973 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
RG72_RS13210 2517053..2517583 - 531 WP_000055072.1 inorganic diphosphatase -
RG72_RS13215 2517893..2518849 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
RG72_RS13225 2519159..2520661 + 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
RG72_RS13230 2520675..2521697 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T51692 WP_000239579.1 NZ_CP010238:2516623-2516973 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T51692 NZ_CP010238:2516623-2516973 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT51692 WP_001223207.1 NZ_CP010238:2516378-2516629 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT51692 NZ_CP010238:2516378-2516629 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References