Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 604413..605038 Replicon chromosome
Accession NZ_CP010238
Organism Escherichia coli strain S50

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag RG72_RS03280 Protein ID WP_000911329.1
Coordinates 604413..604811 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag RG72_RS03285 Protein ID WP_000450524.1
Coordinates 604811..605038 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG72_RS03260 600291..600491 + 201 WP_000383836.1 YpfN family protein -
RG72_RS03265 600601..601299 - 699 WP_000679823.1 esterase -
RG72_RS03270 601373..603388 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
RG72_RS03275 603403..604266 - 864 WP_001267498.1 neutral zinc metallopeptidase -
RG72_RS03280 604413..604811 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
RG72_RS03285 604811..605038 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
RG72_RS03290 605193..605906 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
RG72_RS03300 606119..607153 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
RG72_RS03305 607170..608048 - 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
RG72_RS03310 608194..608766 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
RG72_RS03315 608766..609236 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T51685 WP_000911329.1 NZ_CP010238:c604811-604413 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T51685 NZ_CP010238:c604811-604413 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT51685 WP_000450524.1 NZ_CP010238:c605038-604811 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT51685 NZ_CP010238:c605038-604811 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References