Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 873046..873833 Replicon chromosome
Accession NZ_CP010237
Organism Escherichia coli strain S43

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2H9G3C1
Locus tag RG71_RS04820 Protein ID WP_001568519.1
Coordinates 873456..873833 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2H9G3E7
Locus tag RG71_RS04815 Protein ID WP_000066236.1
Coordinates 873046..873405 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG71_RS27585 868742..868888 + 147 WP_023563913.1 hypothetical protein -
RG71_RS04775 868901..869116 + 216 WP_041036768.1 hypothetical protein -
RG71_RS04780 869230..869640 + 411 WP_042851426.1 hypothetical protein -
RG71_RS26600 869706..870644 + 939 WP_023564414.1 hypothetical protein -
RG71_RS04790 870733..871551 + 819 WP_016236913.1 DUF945 domain-containing protein -
RG71_RS04800 871819..872289 + 471 WP_000131762.1 antirestriction protein -
RG71_RS04805 872301..872780 + 480 WP_000437750.1 DNA repair protein RadC -
RG71_RS04810 872801..873022 + 222 WP_000691981.1 DUF987 domain-containing protein -
RG71_RS04815 873046..873405 + 360 WP_000066236.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG71_RS04820 873456..873833 + 378 WP_001568519.1 TA system toxin CbtA family protein Toxin
RG71_RS04825 873830..874321 + 492 WP_000777682.1 hypothetical protein -
RG71_RS04830 874353..874556 + 204 WP_000413747.1 DUF957 domain-containing protein -
RG71_RS04835 874637..875482 + 846 WP_016236912.1 DUF4942 domain-containing protein -
RG71_RS04845 875824..876555 - 732 WP_001340895.1 DNA polymerase III subunit epsilon -
RG71_RS04850 876620..877087 + 468 WP_000917883.1 ribonuclease HI -
RG71_RS04855 877084..877806 - 723 WP_001326702.1 class I SAM-dependent methyltransferase -
RG71_RS04860 877840..878595 + 756 WP_001052715.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR / tssM / tssA / hcp1/tssD1 760064..878595 118531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14211.00 Da        Isoelectric Point: 7.4209

>T51664 WP_001568519.1 NZ_CP010237:873456-873833 [Escherichia coli]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKTTGLMTRNDYRTVTDITTGKYRGGHR

Download         Length: 378 bp

>T51664 NZ_CP010237:873456-873833 [Escherichia coli]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCATTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAACCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13127.02 Da        Isoelectric Point: 7.0261

>AT51664 WP_000066236.1 NZ_CP010237:873046-873405 [Escherichia coli]
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 360 bp

>AT51664 NZ_CP010237:873046-873405 [Escherichia coli]
TTGTCGAATAAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGTCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
GGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H9G3C1

Antitoxin

Source ID Structure
AlphaFold DB A0A2H9G3E7

References