Detailed information of TA system TA051655

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3015302..3016137
• Replicon: chromosome
• Accession: NZ_CP010236
• Organism: Escherichia coli strain S42

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: E3PD61
• Locus tag: RG70_RS15735
• Protein ID: WP_001094449.1
• Coordinates: 3015760..3016137 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: RG70_RS15730
• Protein ID: WP_061330307.1
• Coordinates: 3015302..3015670 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG70_RS15685	3011384..3011839	+	456	WP_000581511.1	hypothetical protein	-
RG70_RS15690	3011918..3012151	+	234	WP_073520517.1	DUF905 family protein	-
RG70_RS15700	3012251..3013072	+	822	WP_073520518.1	DUF945 domain-containing protein	-
RG70_RS15710	3013374..3013847	+	474	WP_000855079.1	antirestriction protein	-
RG70_RS15715	3013863..3014339	+	477	WP_001186771.1	RadC family protein	-
RG70_RS15720	3014402..3014623	+	222	WP_000692315.1	DUF987 domain-containing protein	-
RG70_RS15725	3014642..3015286	+	645	WP_073520519.1	antitoxin of toxin-antitoxin stability system	-
RG70_RS15730	3015302..3015670	+	369	WP_061330307.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
RG70_RS15735	3015760..3016137	+	378	WP_001094449.1	TA system toxin CbtA family protein	Toxin
RG70_RS25790	3016134..3016304	+	171	Protein_2861	hypothetical protein	-
RG70_RS25795	3016359..3016556	+	198	WP_087891818.1	DUF957 domain-containing protein	-
RG70_RS15745	3016641..3017486	+	846	WP_001290175.1	DUF4942 domain-containing protein	-
RG70_RS15750	3017557..3019092	+	1536	WP_000492893.1	EAL domain-containing protein	-
RG70_RS15755	3019427..3019963	-	537	WP_000942795.1	GspM family type II secretion system protein YghD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14162.00 Da
• Isoelectric Point: 6.6312

>T51655 WP_001094449.1 NZ_CP010236:3015760-3016137 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SSCTHSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T51655 NZ_CP010236:3015760-3016137 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCAGCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13782.61 Da
• Isoelectric Point: 5.8808

>AT51655 WP_061330307.1 NZ_CP010236:3015302-3015670 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT51655 NZ_CP010236:3015302-3015670 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: E3PD61