51641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1354464..1355102 Replicon chromosome
Accession NZ_CP010236
Organism Escherichia coli strain S42

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag RG70_RS07135 Protein ID WP_000813794.1
Coordinates 1354464..1354640 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag RG70_RS07140 Protein ID WP_001270285.1
Coordinates 1354686..1355102 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG70_RS07115 1350083..1351297 - 1215 WP_071601296.1 BenE family transporter YdcO -
RG70_RS07120 1351350..1351886 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
RG70_RS07125 1351959..1353920 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
RG70_RS07130 1354012..1354242 - 231 WP_000494244.1 YncJ family protein -
RG70_RS07135 1354464..1354640 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
RG70_RS07140 1354686..1355102 + 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
RG70_RS07145 1355181..1356587 + 1407 WP_000760594.1 PLP-dependent aminotransferase family protein -
RG70_RS07150 1356832..1357977 + 1146 WP_039022646.1 ABC transporter substrate-binding protein -
RG70_RS07155 1357995..1359008 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
RG70_RS07160 1359009..1359950 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1348895..1350043 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T51641 WP_000813794.1 NZ_CP010236:1354464-1354640 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T51641 NZ_CP010236:1354464-1354640 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT51641 WP_001270285.1 NZ_CP010236:1354686-1355102 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT51641 NZ_CP010236:1354686-1355102 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References