Detailed information of TA system TA051512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 2602235..2602940
• Replicon: chromosome
• Accession: NZ_CP010226
• Organism: Escherichia coli strain S1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: RG64_RS14205
• Protein ID: WP_000539521.1
• Coordinates: 2602235..2602621 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: RG64_RS14210
• Protein ID: WP_001280945.1
• Coordinates: 2602611..2602940 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG64_RS14185	2598239..2598865	+	627	WP_016241992.1	glutathione S-transferase GstB	-
RG64_RS14190	2598862..2599977	-	1116	WP_000555031.1	aldose sugar dehydrogenase YliI	-
RG64_RS14195	2600088..2600471	-	384	WP_000497137.1	biofilm formation regulator BssR	-
RG64_RS14200	2600684..2602009	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
RG64_RS14205	2602235..2602621	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RG64_RS14210	2602611..2602940	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
RG64_RS14215	2603010..2604338	-	1329	WP_000086877.1	GGDEF domain-containing protein	-
RG64_RS14220	2604346..2606694	-	2349	WP_073527570.1	EAL domain-containing protein	-
RG64_RS14225	2606872..2607783	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T51512 WP_000539521.1 NZ_CP010226:2602235-2602621 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T51512 NZ_CP010226:2602235-2602621 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT51512 WP_001280945.1 NZ_CP010226:2602611-2602940 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT51512 NZ_CP010226:2602611-2602940 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCATTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6