Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1922141..1922667 Replicon chromosome
Accession NZ_CP010226
Organism Escherichia coli strain S1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag RG64_RS10560 Protein ID WP_000323025.1
Coordinates 1922141..1922428 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag RG64_RS10565 Protein ID WP_000534858.1
Coordinates 1922428..1922667 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG64_RS10525 1917823..1918782 - 960 WP_000592549.1 DUF523 and DUF1722 domain-containing protein -
RG64_RS10530 1918975..1919499 + 525 WP_000780584.1 lipocalin family protein -
RG64_RS10535 1919655..1920032 - 378 WP_001204787.1 antitermination protein -
RG64_RS10540 1920050..1921099 - 1050 WP_001515372.1 DUF968 domain-containing protein -
RG64_RS10545 1921101..1921379 - 279 WP_001515373.1 hypothetical protein -
RG64_RS10550 1921446..1921697 - 252 WP_001463433.1 hypothetical protein -
RG64_RS10555 1921914..1922069 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
RG64_RS10560 1922141..1922428 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
RG64_RS10565 1922428..1922667 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
RG64_RS10570 1922692..1922997 + 306 WP_071593935.1 hypothetical protein -
RG64_RS10580 1923200..1923532 + 333 WP_001301033.1 protein FlxA -
RG64_RS27075 1923969..1924121 - 153 WP_187658858.1 hypothetical protein -
RG64_RS10590 1924113..1924391 - 279 Protein_1883 hypothetical protein -
RG64_RS10600 1924494..1925656 + 1163 WP_085947771.1 IS3-like element IS3 family transposase -
RG64_RS10605 1925670..1925864 - 195 WP_073527387.1 transcriptional regulator -
RG64_RS10610 1925945..1926352 + 408 WP_000381212.1 helix-turn-helix domain-containing protein -
RG64_RS10615 1926521..1926676 + 156 WP_000379588.1 DUF1391 family protein -
RG64_RS10625 1926836..1927054 + 219 WP_001171952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimA 1905205..1943200 37995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T51511 WP_000323025.1 NZ_CP010226:c1922428-1922141 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T51511 NZ_CP010226:c1922428-1922141 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT51511 WP_000534858.1 NZ_CP010226:c1922667-1922428 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT51511 NZ_CP010226:c1922667-1922428 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References