51449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3358553..3359148 Replicon chromosome
Accession NZ_CP010219
Organism Escherichia coli strain M18

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag RG62_RS17505 Protein ID WP_000239579.1
Coordinates 3358798..3359148 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2J1DIF8
Locus tag RG62_RS17500 Protein ID WP_001223209.1
Coordinates 3358553..3358804 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG62_RS17490 3354218..3357997 + 3780 WP_000060927.1 autotransporter assembly complex protein TamB -
RG62_RS17495 3358000..3358341 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
RG62_RS17500 3358553..3358804 + 252 WP_001223209.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
RG62_RS17505 3358798..3359148 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
RG62_RS17510 3359228..3359758 - 531 WP_000055075.1 inorganic diphosphatase -
RG62_RS17515 3360068..3361024 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
RG62_RS17520 3361164..3362666 + 1503 WP_000205810.1 sugar ABC transporter ATP-binding protein -
RG62_RS17525 3362680..3363702 + 1023 WP_024251350.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T51449 WP_000239579.1 NZ_CP010219:3358798-3359148 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T51449 NZ_CP010219:3358798-3359148 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.4201

>AT51449 WP_001223209.1 NZ_CP010219:3358553-3358804 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWSKSTPAGD
EIW

Download         Length: 252 bp

>AT51449 NZ_CP010219:3358553-3358804 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGAGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J1DIF8

References