Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4019027..4019825 Replicon chromosome
Accession NZ_CP010213
Organism Escherichia coli strain M15

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag RG61_RS20985 Protein ID WP_021573868.1
Coordinates 4019448..4019825 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag RG61_RS20980 Protein ID WP_073519787.1
Coordinates 4019027..4019401 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG61_RS20930 4014598..4014846 + 249 WP_001313576.1 hypothetical protein -
RG61_RS20935 4015002..4015454 + 453 WP_000682723.1 hypothetical protein -
RG61_RS20940 4015572..4015805 + 234 WP_001213776.1 DUF905 family protein -
RG61_RS20950 4015905..4016726 + 822 WP_021567056.1 DUF945 domain-containing protein -
RG61_RS20955 4016726..4016971 + 246 WP_001164966.1 hypothetical protein -
RG61_RS20960 4017065..4017538 + 474 WP_001313575.1 antirestriction protein -
RG61_RS20965 4017554..4018030 + 477 WP_001186193.1 RadC family protein -
RG61_RS20970 4018093..4018314 + 222 WP_000692300.1 DUF987 domain-containing protein -
RG61_RS20975 4018333..4018977 + 645 WP_073519465.1 antitoxin of toxin-antitoxin stability system -
RG61_RS20980 4019027..4019401 + 375 WP_073519787.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG61_RS20985 4019448..4019825 + 378 WP_021573868.1 TA system toxin CbtA family protein Toxin
RG61_RS20990 4019822..4020314 + 493 Protein_3854 hypothetical protein -
RG61_RS21000 4020393..4021381 - 989 Protein_3855 IS630 family transposase -
RG61_RS21010 4021553..4023122 - 1570 Protein_3856 IS66 family transposase -
RG61_RS21015 4023153..4023503 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
RG61_RS21020 4023500..4023791 - 292 Protein_3858 transposase -
RG61_RS21025 4023833..4024027 + 195 WP_001313570.1 DUF957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14299.33 Da        Isoelectric Point: 6.8531

>T51408 WP_021573868.1 NZ_CP010213:4019448-4019825 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILLTRRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T51408 NZ_CP010213:4019448-4019825 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCACGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACTCTGAATGACACACCATTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATTCTCCTGACCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13880.67 Da        Isoelectric Point: 6.3118

>AT51408 WP_073519787.1 NZ_CP010213:4019027-4019401 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPCHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTLAPATTS

Download         Length: 375 bp

>AT51408 NZ_CP010213:4019027-4019401 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCTGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References