Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3831826..3832661 Replicon chromosome
Accession NZ_CP010213
Organism Escherichia coli strain M15

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag RG61_RS19980 Protein ID WP_049590183.1
Coordinates 3831826..3832203 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag RG61_RS19985 Protein ID WP_049590182.1
Coordinates 3832293..3832661 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG61_RS19950 3827084..3828040 + 957 WP_000121330.1 molybdenum cofactor insertion chaperone PaoD -
RG61_RS19955 3828019..3828429 + 411 WP_001111349.1 transcriptional regulator -
RG61_RS19960 3828767..3830086 + 1320 WP_049590185.1 site-specific integrase -
RG61_RS19965 3830179..3831027 - 849 WP_049590184.1 DUF4942 domain-containing protein -
RG61_RS19970 3831124..3831321 - 198 WP_000772024.1 DUF957 domain-containing protein -
RG61_RS19975 3831341..3831829 - 489 WP_000761700.1 hypothetical protein -
RG61_RS19980 3831826..3832203 - 378 WP_049590183.1 TA system toxin CbtA family protein Toxin
RG61_RS19985 3832293..3832661 - 369 WP_049590182.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG61_RS19990 3832711..3833358 - 648 WP_049590180.1 hypothetical protein -
RG61_RS19995 3833377..3833598 - 222 WP_000692300.1 DUF987 domain-containing protein -
RG61_RS20000 3833667..3834143 - 477 WP_001186724.1 RadC family protein -
RG61_RS20005 3834159..3834638 - 480 WP_000706981.1 antirestriction protein -
RG61_RS20010 3834732..3834977 - 246 WP_024196226.1 hypothetical protein -
RG61_RS20015 3834977..3835795 - 819 WP_001234639.1 DUF945 domain-containing protein -
RG61_RS20020 3835816..3835923 - 108 WP_071526136.1 cytoplasmic protein -
RG61_RS20030 3836079..3836534 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagX/ecpC / yagW/ecpD / yagV/ecpE 3802671..3833358 30687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13984.01 Da        Isoelectric Point: 9.6545

>T51407 WP_049590183.1 NZ_CP010213:c3832203-3831826 [Escherichia coli]
MKTLPVLPGQSASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITRGKHPEAKR

Download         Length: 378 bp

>T51407 NZ_CP010213:c3832203-3831826 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGTCGGCCAGTTCACGCCCATCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCGGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.64 Da        Isoelectric Point: 6.9371

>AT51407 WP_049590182.1 NZ_CP010213:c3832661-3832293 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPCHQHTVTLYARGLICEADTFGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT51407 NZ_CP010213:c3832661-3832293 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACTAGCGGT
GAACTGAATCCCTGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGATCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References