Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 780859..781693 | Replicon | chromosome |
| Accession | NZ_CP010213 | ||
| Organism | Escherichia coli strain M15 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | RG61_RS04100 | Protein ID | WP_073519464.1 |
| Coordinates | 780859..781236 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2TSS6 |
| Locus tag | RG61_RS04105 | Protein ID | WP_012908802.1 |
| Coordinates | 781325..781693 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG61_RS04070 | 776135..776734 | + | 600 | WP_001255040.1 | type II secretion system minor pseudopilin GspJ | - |
| RG61_RS04075 | 776737..777714 | + | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| RG61_RS04080 | 777711..778889 | + | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| RG61_RS04085 | 778891..779427 | + | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| RG61_RS04090 | 779792..780355 | - | 564 | WP_073519462.1 | DUF4942 domain-containing protein | - |
| RG61_RS28675 | 780440..780637 | - | 198 | WP_089560254.1 | DUF957 domain-containing protein | - |
| RG61_RS28680 | 780713..780862 | - | 150 | Protein_745 | malate transporter | - |
| RG61_RS04100 | 780859..781236 | - | 378 | WP_073519464.1 | TA system toxin CbtA family protein | Toxin |
| RG61_RS04105 | 781325..781693 | - | 369 | WP_012908802.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| RG61_RS04110 | 781743..782387 | - | 645 | WP_073519465.1 | antitoxin of toxin-antitoxin stability system | - |
| RG61_RS04115 | 782406..782627 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| RG61_RS04120 | 782690..783166 | - | 477 | WP_041124171.1 | RadC family protein | - |
| RG61_RS04125 | 783182..783661 | - | 480 | WP_061892567.1 | antirestriction protein | - |
| RG61_RS28075 | 783760..783960 | + | 201 | WP_077768309.1 | hypothetical protein | - |
| RG61_RS04135 | 783978..784796 | - | 819 | WP_061892566.1 | DUF945 domain-containing protein | - |
| RG61_RS28685 | 784887..785044 | - | 158 | Protein_754 | septum formation initiator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 7.7294
>T51389 WP_073519464.1 NZ_CP010213:c781236-780859 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T51389 NZ_CP010213:c781236-780859 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAACAGCATATTG
AGGCGGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCTCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATCGATATCCTCCGGGCACGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAACAGCATATTG
AGGCGGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCTCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATCGATATCCTCCGGGCACGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13829.62 Da Isoelectric Point: 6.9465
>AT51389 WP_012908802.1 NZ_CP010213:c781693-781325 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK
Download Length: 369 bp
>AT51389 NZ_CP010213:c781693-781325 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|