Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 21485..21966 Replicon plasmid A
Accession NZ_CP010207
Organism Escherichia coli strain M11

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag RG60_RS26405 Protein ID WP_073519917.1
Coordinates 21751..21966 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag RG60_RS26400 Protein ID WP_073519918.1
Coordinates 21485..21754 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG60_RS26335 16760..16972 + 213 WP_032334799.1 hypothetical protein -
RG60_RS26340 17215..17675 + 461 Protein_21 thermonuclease family protein -
RG60_RS26345 17721..17930 + 210 WP_032334801.1 hemolysin expression modulator Hha -
RG60_RS26350 17968..18558 + 591 WP_032334802.1 DUF2726 domain-containing protein -
RG60_RS26355 18538..18780 - 243 WP_071996372.1 hypothetical protein -
- 18731..18787 - 57 NuclAT_1 - -
- 18731..18787 - 57 NuclAT_1 - -
- 18731..18787 - 57 NuclAT_1 - -
- 18731..18787 - 57 NuclAT_1 - -
RG60_RS26360 18836..18985 + 150 WP_001312851.1 type I toxin-antitoxin system Hok family toxin -
RG60_RS26365 19186..19443 + 258 WP_073519922.1 replication regulatory protein RepA -
RG60_RS26370 19460..19608 - 149 Protein_27 replication protein RepA -
RG60_RS26375 19675..19749 + 75 WP_001365705.1 RepA leader peptide Tap -
RG60_RS26380 19742..20570 + 829 Protein_29 incFII family plasmid replication initiator RepA -
RG60_RS26385 20932..21126 + 195 WP_073519921.1 replication protein -
RG60_RS26390 21142..21273 - 132 WP_071595370.1 replication protein RepA4 -
RG60_RS26400 21485..21754 + 270 WP_073519918.1 hypothetical protein Antitoxin
RG60_RS26405 21751..21966 + 216 WP_073519917.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG60_RS26410 22118..22423 + 306 WP_073521420.1 hypothetical protein -
RG60_RS26415 22420..22692 - 273 WP_046201741.1 hypothetical protein -
RG60_RS26420 22685..23224 - 540 WP_077897976.1 recombinase family protein -
RG60_RS29135 23382..23465 + 84 Protein_37 maturase -
RG60_RS29140 23699..24061 + 363 WP_071597330.1 hypothetical protein -
RG60_RS26430 24086..24286 + 201 WP_073519915.1 hypothetical protein -
RG60_RS26435 24291..24926 + 636 WP_073519914.1 CPBP family intramembrane metalloprotease -
RG60_RS26440 25029..26282 + 1254 WP_073519913.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pic / faeC / faeD / faeE / faeF / faeH / faeI 1..138950 138950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-64)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8017.24 Da        Isoelectric Point: 6.4468

>T51379 WP_073519917.1 NZ_CP010207:21751-21966 [Escherichia coli]
MMEIFCTMLASQDRKRIREYIAEQNLMAAIELDELIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFCSGL

Download         Length: 216 bp

>T51379 NZ_CP010207:21751-21966 [Escherichia coli]
ATGATGGAGATATTCTGTACTATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACTGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCCCATTTTTGTTCTGGTTTATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10310.62 Da        Isoelectric Point: 6.4710

>AT51379 WP_073519918.1 NZ_CP010207:21485-21754 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEEGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT51379 NZ_CP010207:21485-21754 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGAAGGACGTCAGCAACTCGAGCGCGGTGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References