Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3165616..3166414 Replicon chromosome
Accession NZ_CP010206
Organism Escherichia coli strain M11

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag RG60_RS16575 Protein ID WP_021573868.1
Coordinates 3166037..3166414 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag RG60_RS16570 Protein ID WP_073519787.1
Coordinates 3165616..3165990 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG60_RS16520 3161187..3161435 + 249 WP_001313576.1 hypothetical protein -
RG60_RS16525 3161591..3162043 + 453 WP_000682723.1 hypothetical protein -
RG60_RS16530 3162161..3162394 + 234 WP_001213776.1 DUF905 family protein -
RG60_RS16540 3162494..3163315 + 822 WP_021567056.1 DUF945 domain-containing protein -
RG60_RS16545 3163315..3163560 + 246 WP_001164966.1 hypothetical protein -
RG60_RS16550 3163654..3164127 + 474 WP_001313575.1 antirestriction protein -
RG60_RS16555 3164143..3164619 + 477 WP_001186193.1 RadC family protein -
RG60_RS16560 3164682..3164903 + 222 WP_000692300.1 DUF987 domain-containing protein -
RG60_RS16565 3164922..3165566 + 645 WP_073519465.1 antitoxin of toxin-antitoxin stability system -
RG60_RS16570 3165616..3165990 + 375 WP_073519787.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG60_RS16575 3166037..3166414 + 378 WP_021573868.1 TA system toxin CbtA family protein Toxin
RG60_RS16580 3166411..3166903 + 493 Protein_3051 hypothetical protein -
RG60_RS16590 3166982..3167970 - 989 Protein_3052 IS630 family transposase -
RG60_RS16600 3168142..3169711 - 1570 Protein_3053 IS66 family transposase -
RG60_RS16605 3169742..3170092 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
RG60_RS16610 3170089..3170380 - 292 Protein_3055 transposase -
RG60_RS16615 3170422..3170616 + 195 WP_001313570.1 DUF957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14299.33 Da        Isoelectric Point: 6.8531

>T51373 WP_021573868.1 NZ_CP010206:3166037-3166414 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILLTRRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T51373 NZ_CP010206:3166037-3166414 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCACGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACTCTGAATGACACACCATTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATTCTCCTGACCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13880.67 Da        Isoelectric Point: 6.3118

>AT51373 WP_073519787.1 NZ_CP010206:3165616-3165990 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPCHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTLAPATTS

Download         Length: 375 bp

>AT51373 NZ_CP010206:3165616-3165990 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCTGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References